The DOI matches its Crossref record.
Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection
Open accessAbstract
It has been known for a number of years that integration sites of human immunodeficiency virus type 1 (HIV-1) DNA show a preference for actively expressed chromosomal locations. A number of viral and cellular proteins are implicated in this process, but the underlying mechanism is not clear. Two recent breakthrough publications advance our understanding of HIV integration site selection by focusing on the localization of the preferred target genes of integration. These studies reveal that knockdown of certain nucleoporins and components of nucleocytoplasmic trafficking alter integration site preference, not by altering the trafficking of the viral genome but by altering the chromatin subtype localization relative to the structure of the nucleus. Here, we describe the link between the nuclear basket nucleoporins (Tpr and Nup153) and chromatin organization and how altering the host environment by manipulating nuclear structure may have important implications for the preferential integration of HIV into actively transcribed genes, facilitating efficient viral replication.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In non-dividing cells, proximity to the nuclear pore plays a role in integration site selection.
“In non-dividing cells, proximity to the nuclear pore also plays a role in integration site selection [22].”
From Clinical use of lentiviral vectors (2018) · cites this paper as [22]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 20
- 10.1016/j.bbamcr.2010.12.009 · DOI
- 10.1016/j.virusres.2013.09.003 · DOI
- 10.1016/j.coviro.2013.11.003 · DOI
- 10.3390/v5102483 · DOI
- 10.1038/ncomms7483 · DOI
- 10.1038/nature14226 · DOI
- 10.1038/nrm2928 · DOI
- 10.1101/gad.256495.114 · DOI
- 10.1111/febs.13163 · DOI
- 10.1073/pnas.82.24.8527 · DOI
- 10.1091/mbc.E02-09-0620 · DOI
- 10.1128/JVI.00325-11 · DOI
- 10.1186/1742-4690-10-77 · DOI
- 10.1371/journal.ppat.1003693 · DOI · Paper page
- 10.1080/15384101.2015.1021518 · DOI
- 10.1074/jbc.M110.105890 · DOI
- 10.1038/emboj.2010.54 · DOI
- 10.1128/JVI.00476-15 · DOI
- 10.1128/JVI.02219-14 · DOI
- 10.1038/nrmicro3466 · DOI
Cited by
Sorted by citations
Clinical use of lentiviral vectors
Milone, M. C., & O’Doherty, U. (2018) · Leukemia · doi:10.1038/s41375-018-0106-0 · Cited by 930
“proximity to the nuclear pore also plays a role in integration site selection [22].”
Background
Metadata
- Authors
- Wong, R. W., Mamede, J. I., & Hope, T. J.
- Affiliations
- Kanazawa University (JP)
- Northwestern University (US)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2015-10
- Volume
- 89
- Issue
- 19
- Pages
- 9702-9705
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC4577903
- OpenAlex
- W2155321442
- Cited by
- 45
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 2 · 2016: 8 · 2015: 2
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Takeda Science Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health
- Japan Society for the Promotion of Science (26640071)
- National Institute of General Medical Sciences (P50GM082545)
- National Institute of Allergy and Infectious Diseases (R01AI127302)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- nucleoporins, TPR, Nup153, nuclear basket, chromatin localization, nuclear organization, nucleocytoplasmic trafficking, chromatin organization, viral replication
- MeSH terms
- Cell Nucleus, Chromatin, HeLa Cells, Humans, Microscopy, Electron, HIV-1, HIV Infections, Virus Integration, Nuclear Pore Complex Proteins, Virus Attachment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
