The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus
Open accessAbstract
Bats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic relationship. In this study, evidence of the recombinant origin of the genome of a bat SLCoV is demonstrated. We identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the S coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other CoVs. Phylogenetic analysis of its parental regions suggests the presence of an uncharacterized SLCoV lineage that is phylogenetically closer to SCoVs than any of the currently sampled bat SLCoVs. Using various Bayesian molecular-clock models, interspecies transfer of this SLCoV lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the SARS outbreak. Based on this relatively short window period, we speculate that this uncharacterized SLCoV lineage may contain the direct ancestor of SCoV. This study sheds light on the possible host bat species of the direct ancestor of SCoV, providing valuable information on the scope and focus of surveillance for the origin of SCoV.
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Citations
Cites
Relaxed Phylogenetics and Dating with Confidence
Drummond, A. J., Ho, S. Y. W., Phillips, M. J., & Rambaut, A. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040088 · Cited by 6,463 · cited 2×
“tree prior, which assumes a constant speciation rate per lineage (6).”
BackgroundSelf-citationDrummond, A. J., Nicholls, G. K., Rodrigo, A. G., & Solomon, W. (2002) · Genetics · doi:10.1093/genetics/161.3.1307 · Cited by 1,059
Self-citationEstimation of primate speciation dates using local molecular clocks.
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Moderate mutation rate in the SARS coronavirus genome and its implications
Zhao, Z., Li, H., Wu, X., Zhong, Y., Zhang, K., Zhang, Y.-P., Boerwinkle, E., & Fu, Y.-X. (2004) · BMC Evolutionary Biology · doi:10.1186/1471-2148-4-21 · Cited by 286
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“In contrast, if the data set is clocklike, assumption of a molecular clock increases the precision of rate estimates without compromising accuracy (14).”
Background
Cited by
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
Ge, X.-Y., Li, J.-L., Yang, X.-L., Chmura, A. A., Zhu, G., Epstein, J. H., Mazet, J. K., Hu, B., Zhang, W., Peng, C., et al. (2013) · Nature · doi:10.1038/nature12711 · Cited by 1,778
Self-citationEvolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
Boni, M. F., Lemey, P., Jiang, X., Lam, T. T.-Y., Perry, B. W., Castoe, T. A., Rambaut, A., & Robertson, D. L. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0771-4 · Cited by 1,014
“5 / 25 permitting generation of novel viral variants, as reported by others (He et al., 2014; Hon et al., 2008; Hu et al., 2017; Li et al., 2020b; Lin et al., 2017; Wang et al., 2017; Yuan et al., 2010; Zhou et al., 2020a).”
BackgroundMethodResultInfluentialSelf-citationCross-Species Virus Transmission and the Emergence of New Epidemic Diseases
Parrish, C. R., Holmes, E. C., Morens, D. M., Park, E.-C., Burke, D. S., Calisher, C. H., Laughlin, C. A., Saif, L. J., & Daszak, P. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00004-08 · Cited by 834
Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS
Drexler, J. F., Corman, V. M., & Drosten, C. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2013.10.013 · Cited by 406
Emergence and control of infectious diseases in China
Wang, L., Wang, Y., Jin, S., Wu, Z., Chin, D. P., Koplan, J. P., & Wilson, M. E. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61365-3 · Cited by 390
Metadata
- Authors
- Hon, C.-C., Lam, T.-Y., Shi, Z.-L., Drummond, A. J., Yip, C.-W., Zeng, F., Lam, P.-Y., & Leung, F. C.-C.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2008-02-15
- Volume
- 82
- Issue
- 4
- Pages
- 1819-1826
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2144073791
- Cited by
- 217
- References
- 5
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus. https://app.cochat.ai/papers/10.1128/jvi.01926-07
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- Hon, C.-C., Lam, T.-Y., Shi, Z.-L., Drummond, A. J., Yip, C.-W., Zeng, F., Lam, P.-Y., & Leung, F. C.-C. (2008). Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus. Journal of Virology. https://doi.org/10.1128/jvi.01926-07
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