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Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus
Open accessAbstract
Recurrent outbreaks of highly pathogenic avian influenza virus pose the threat of pandemic spread of lethal disease and make it a priority to develop safe and effective vaccines. Influenza virus-like particles (VLPs) have been suggested to be a promising vaccine approach. However, VLP-induced immune responses, and their roles in inducing memory immune responses and cross-protective immunity have not been investigated. In this study, we developed VLPs containing influenza virus A/PR8/34 (H1N1) hemagglutinin (HA) and matrix (M1) proteins and investigated their immunogenicity, long-term cross-protective efficacy, and effects on lung proinflammatory cytokines in mice. Intranasal immunization with VLPs containing HA induced high serum and mucosal antibody titers and neutralizing activity against PR8 and A/WSN/33 (H1N1) viruses. Mice immunized with VLPs containing HA showed little or no proinflammatory lung cytokines and were protected from a lethal challenge with mouse-adapted PR8 or WSN viruses even 5 months postimmunization. Influenza VLPs induced mucosal immunoglobulin G and cellular immune responses, which were reactivated rapidly upon virus challenge. Long-lived antibody-secreting cells were detected in the bone marrow of immunized mice. Immune sera administered intranasally were able to confer 100% protection from a lethal challenge with PR8 or WSN, which provides further evidence that anti-HA antibodies are primarily responsible for preventing infection. Taken together, these results indicate that nonreplicating influenza VLPs represent a promising strategy for the development of a safe and effective vaccine to control the spread of lethal influenza viruses.
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Cites
Pushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,950
Evolution and ecology of influenza A viruses
Webster, R. G., Bean, W. J., Gorman, O. T., Chambers, T. M., & Kawaoka, Y. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.152-179.1992 · Cited by 4,739
CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.
Zhou, L. J., & Tedder, T. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2588 · Cited by 1,067
Role of hemagglutinin cleavage for the pathogenicity of influenza virus.
Steinhauer, D. A. (1999) · Virology · doi:10.1006/viro.1999.9716 · Cited by 663
Harro, C. D., Pang, Y.-Y. S., Roden, R. B. S., Hildesheim, A., Wang, Z., Reynolds, M. J., Mast, T. C., Robinson, R., Murphy, B. R., Karron, R. A., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.284 · Cited by 607
Characterization of Avian H5N1 Influenza Viruses from Poultry in Hong Kong
Shortridge, K. F., Zhou, N. N., Guan, Y., Gao, P., Ito, T., Kawaoka, Y., Kodihalli, S., Krauss, S., Markwell, D., Murti, K. G., et al. (1998) · Virology · doi:10.1006/viro.1998.9488 · Cited by 589
Oxygen Radicals in Influenza-Induced Pathogenesis and Treatment with Pyran Polymer-Conjugated SOD
Oda, T., Akaike, T., Hamamoto, T., Suzuki, F., Hirano, T., & Maeda, H. (1989) · Science · doi:10.1126/science.2543070 · Cited by 418
Assembly and budding of influenza virus
Nayak, D. P., Hui, E. K.-W., & Barman, S. (2004) · Virus Research · doi:10.1016/j.virusres.2004.08.012 · Cited by 379
The Immune Response to Influenza Infection
Ada, G. L., & Jones, P. D. (1986) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-71272-2_1 · Cited by 316
Influenza Virus Matrix Protein Is the Major Driving Force in Virus Budding
Gómez-Puertas, P., Albo, C., Pérez-Pastrana, E., Vivo, A., & Portela, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11538-11547.2000 · Cited by 287
Research works printed but not linked: 14
- 10.1016/j.vaccine.2006.03.089 · doi:10.1016/j.vaccine.2006.03.089
- 10.1016/0168-1702(85)90006-1 · doi:10.1016/0168-1702(85)90006-1
- 10.1016/S0264-410X(98)00494-0 · doi:10.1016/s0264-410x(98)00494-0
- 10.1128/JVI.78.18.9624-9632.2004 · doi:10.1128/jvi.78.18.9624-9632.2004
- 10.1182/blood-2004-04-1453 · doi:10.1182/blood-2004-04-1453
- 10.1128/jvi.63.4.1549-1557.1989 · doi:10.1128/jvi.63.4.1549-1557.1989
- 10.1128/JVI.75.13.6154-6165.2001 · doi:10.1128/jvi.75.13.6154-6165.2001
- 10.1128/JVI.79.15.10003-10012.2005 · doi:10.1128/jvi.79.15.10003-10012.2005
- 10.1128/JVI.72.4.3390-3393.1998 · doi:10.1128/jvi.72.4.3390-3393.1998
- 10.1080/0307945021000070688 · doi:10.1080/0307945021000070688
- Scholtissek, C. 1991. Synthesis and function of influenza A virus glycoproteins. Behring Inst. Mitt.1991:46-53.
- 10.1016/0264-410X(88)90140-5 · doi:10.1016/0264-410x(88)90140-5
- 10.1016/S0140-6736(04)15892-3 · doi:10.1016/s0140-6736(04)15892-3
- Wright, P., and R. Webster. 2001. Orthomyxoviruses, p. 1533-1579. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, PA.
Cited by
Kushnir, N., Streatfield, S. J., & Yusibov, V. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.10.083 · Cited by 587
Nanoparticle-Based Vaccines Against Respiratory Viruses
Al-Halifa, S., Gauthier, L., Arpin, D., Bourgault, S., & Archambault, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00022 · Cited by 299
Brazzoli, M., Magini, D., Bonci, A., Buccato, S., Giovani, C., Kratzer, R., Zurli, V., Mangiavacchi, S., Casini, D., Brito, L. M., et al. (2016) · Journal of Virology · doi:10.1128/jvi.01786-15 · Cited by 154
Viruslike Particle Vaccine Induces Protection Against Respiratory Syncytial Virus Infection in Mice
Quan, F.-S., Kim, Y., Lee, S., Yi, H., Kang, S.-M., Bozja, J., Moore, M. L., & Compans, R. W. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir474 · Cited by 125
Self-citationVirus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii
Lee, D. H., Lee, S. H., Kim, A. R., & Quan, F. S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161231 · Cited by 36
Self-citation
Metadata
- Authors
- Quan, F.-S., Huang, C., Compans, R. W., & Kang, S.-M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-04
- Volume
- 81
- Issue
- 7
- Pages
- 3514-3524
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2152912310
- Cited by
- 313
- References
- 29
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- Quan, F.-S., Huang, C., Compans, R. W., & Kang, S.-M. (2007). Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus. Journal of Virology. https://doi.org/10.1128/jvi.02052-06
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