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Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures
Open accessAbstract
Influenza viral complementary RNA (cRNA), i.e., viral mRNA was radioactive when purified from the cytoplasmic fraction of cordycepin-treated canine kidney cells that were incubated with [methyl-3H]methionine during infection. Approximately 55 to 60% of the methyl-3H radioactivity was in internal N6-methyladenosine, a feature distinguishing this mRNA from those viral mRNA's that are known to be synthesized in the cytoplasm. The remaining methyl-3H radioactivity was in 5'-terminal cap structures that consisted of 7-methylguanosine in pyrophosphate linkage to 2'-o-methyladenosine, N6, 2'-O-dimethyladenosine, or 2'-O-methylguanosine. Methylated adenosine was the predominant penultimate nucleoside in caps, suggesting that cRNA synthesis in infected cells initiates preferentially with adenosine at the 5' end. In contrast to cRNA, influenza virion RNA segments extracted from purified virus contained mainly 5'-terminal ppA and no detectable cap structures.
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Cites
Structure of the poliovirus replicative intermediate RNA
Baltimore, D. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90015-6 · Cited by 123
Cited by
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Kim, D., Lee, J.-Y., Yang, J.-S., Kim, J. W., Kim, V. N., & Chang, H. (2020) · Cell · doi:10.1016/j.cell.2020.04.011 · Cited by 2,123
Bokar, J. A., Rath-Shambaugh, M. E., Ludwiczak, R., Narayan, P., & Rottman, F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32497-3 · Cited by 383
Recent advances in dynamic m 6 A RNA modification
Cao, G., Li, H.-B., Yin, Z., & Flavell, R. A. (2016) · Open Biology · doi:10.1098/rsob.160003 · Cited by 308
Durbin, A. F., Wang, C., Marcotrigiano, J., & Gehrke, L. (2016) · mBio · doi:10.1128/mbio.00833-16 · Cited by 238
Metadata
- Authors
- Krug, R. M., Morgan, M. A., & Shatkin, A. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1976-10
- Volume
- 20
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1584664429
- Cited by
- 289
- References
- 1
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Krug, R. M., Morgan, M. A., & Shatkin, A. J. (1976). Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures. Journal of Virology. https://doi.org/10.1128/jvi.20.1.45-53.1976
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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