The DOI matches its Crossref record.
Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate
Open accessAbstract
The effect of the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) on herpes simplex virus type 1 DNA synthesis was examined. Acycloguanosine inhibited herpesvirus DNA synthesis in virus-infected cells. The synthesis of host cell DNA was only partially inhibited in actively growing cells at acycloguanosine concentrations several hundred-fold greater than the 50% effective dose for herpes simplex virus type 1. Studies using partially purified enzymes revealed that the triphosphate of this compound inhibited the virus-induced DNA polymerases (DNA nucleotidyltransferases) to a greater degree than the DNA polymerase of the host cell, that the inhibition was dependent upon the base composition of the template, and that the triphosphate was a better substrate for the virus-induced polymerases than for the alpha cellular DNA polymerases.
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Citations
Cited by
Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., Lehrman, S. N., Bolognesi, D. P., Broder, S., & Mitsuya, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.21.8333 · Cited by 1,347
Self-citationThe purine path to chemotherapy
Elion, G. B. (1989) · Science · doi:10.1126/science.2649979 · Cited by 687
Self-citationPhosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.
Miller, W. H., & Miller, R. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79686-9 · Cited by 267
Metadata
- Authors
- Furman, P. A., St Clair, M. H., Fyfe, J. A., Rideout, J. L., Keller, P. M., & Elion, G. B.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1979-10
- Volume
- 32
- Issue
- 1
- Pages
- 72-77
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2104796719
- Cited by
- 328
- References
- 0
- FWCI
- 34.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. https://app.cochat.ai/papers/10.1128/jvi.32.1.72-77.1979
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- Furman, P. A., St Clair, M. H., Fyfe, J. A., Rideout, J. L., Keller, P. M., & Elion, G. B. (1979). Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. Journal of Virology. https://doi.org/10.1128/jvi.32.1.72-77.1979
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
