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Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells
Open accessAbstract
Serum raised against a mouse 53,000-dalton (53K) phosphoprotein precipitates both the 53K immunogen and simian virus 40 large-T from lysates of simian virus 40-transformed 3T3 cells. This serum, designated F5, does not recognize antigenic determinants on native or denatured large-T and precipitates large-T because the 53K phosphoprotein forms a stable complex with large-T. This complex sediments at 23S on sucrose density gradients, corresponding to a molecular weight of 600K to 1,000K, and appears to contain only 53K and large-T as major components. It is held together by noncovalent bonds and is located in the cell nucleus. All the 53K immunoprecipitated from cell lysates by F5 is present in the high-molecular-weight complex, but large-T can be separated into a complexed and a free form on sucrose density gradients. The complexed form of large-T is more readily phosphorylated than the free form. We have been unable to detect an association of large-T with comparable host cell proteins during productive infections with simian virus 40.
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Cited by
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,756
Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403
Self-citationMünger, K., Werness, B. A., Dyson, N., Phelps, W. C., Harlow, E., & Howley, P. M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08594.x · Cited by 964
Self-citationUV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.
Maltzman, W., & Czyzyk, L. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.9.1689 · Cited by 893
Sarnow, P., Ho, Y. S., Williams, J., & Levine, A. J. (1982) · Cell · doi:10.1016/0092-8674(82)90356-7 · Cited by 836
Metadata
- Authors
- McCormick, F., & Harlow, E.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1980-04
- Volume
- 34
- Issue
- 1
- Pages
- 213-224
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1534088040
- Cited by
- 203
- References
- 0
- FWCI
- 16.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. https://app.cochat.ai/papers/10.1128/jvi.34.1.213-224.1980
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- McCormick, F., & Harlow, E. (1980). Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. Journal of Virology. https://doi.org/10.1128/jvi.34.1.213-224.1980
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