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Large surface proteins of hepatitis B virus containing the pre-s sequence
Open accessAbstract
The sequence of hepatitis B virus DNA contains an open reading frame which codes for a not-yet-identified protein of at least 389 amino acids. Only the products starting at the third (GP33/GP36) or the fourth (P24/GP27) initiation signal have been characterized as components of the viral surface antigen. We found a larger protein, P39, and its glycosylated form, GP42, in hepatitis B virus particles and viral surface antigen filaments. Immunological cross-reactions showed that P39/GP42 is partially homologous to P24/GP27 and GP33/GP36. The unique portion of its sequence bound monoclonal antibodies which had been induced by immunization with hepatitis B virus particles. Proteolytic cleavage patterns and subtype-specific size differences suggested that the sequence of P39 starts with the first initiation signal of the open reading frame. Its amino-terminal part (pre-s coded) is exposed at the viral surface and, probably, is highly immunogenic. A model is presented of how the open reading frame for the viral envelope leads to defined amounts of three different proteins.
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Cited by
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Yan, H., Zhong, G., Xu, G., He, W., Jing, Z., Gao, Z., Huang, Y., Qi, Y., Peng, B., Wang, H., et al. (2012) · eLife · doi:10.7554/elife.00049 · Cited by 2,115
TENHUNEN, J., SALMINEN, M., LUNDSTRÖM, K., KIVILUOTO, T., SAVOLAINEN, R., & ULMANEN, I. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19083.x · Cited by 331
Metadata
- Authors
- Heermann, K. H., Goldmann, U., Schwartz, W., Seyffarth, T., Baumgarten, H., & Gerlich, W. H.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1984-11
- Volume
- 52
- Issue
- 2
- Pages
- 396-402
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1751218746
- Cited by
- 823
- References
- 0
- FWCI
- 42.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Large surface proteins of hepatitis B virus containing the pre-s sequence. https://app.cochat.ai/papers/10.1128/jvi.52.2.396-402.1984
- The paper
- Heermann, K. H., Goldmann, U., Schwartz, W., Seyffarth, T., Baumgarten, H., & Gerlich, W. H. (1984). Large surface proteins of hepatitis B virus containing the pre-s sequence. Journal of Virology. https://doi.org/10.1128/jvi.52.2.396-402.1984
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
