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Cited by 40T-cell and Retrovirus StudiesHIV Research and TreatmentInfectious Diseases and Mycology

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Truncated gag-related proteins are produced by large deletion mutants of Rous sarcoma virus and form virus particles

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Voynow, S L, Coffin, J M·1985·Journal of Virology
DOI 10.1128/jvi.55.1.79-85.1985PMC PMC254900
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Abstract

Large deletion (LD) mutants of Prague strain Rous sarcoma virus subgroup B (PrB), derived by serial undiluted passage through chicken (C/E) cells, contain two deletions relative to wild-type virus. One of these joins gag sequences in the p12 coding region to env sequences in region encoding gp37; the other deletion spans the src region. Analysis of the viral proteins of QT6 cell clones containing only LD proviruses by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a major truncated gag-related phosphoprotein of 60,000 to 66,000 daltons (P63LD). P63LD was stable, but could be cleaved in vitro to the predicted products by p15gag. A second gag-related LD protein of about 68,000 to 74,000 molecular weight (P70LD) was also found which often reacted with an anti-gp37 serum. P70LD was unstable and may represent a short-lived gag-gp37 fusion protein. Finally, immunoprecipitation indicated that particles containing P63LD were shed from QT6-LD clones. Thin section preparations of these clones viewed in an electron microscope showed enveloped budding particles of "immature" morphology. Thus, the synthesis and release of particles from infected cells does not require cleavage of the gag precursor, nor does it require the presence of p15 or (most of) p12.

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Crossref · 10.1128/jvi.55.1.79-85.1985

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Metadata

Authors
Voynow, S. L., & Coffin, J. M.
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
1985-07
Volume
55
Issue
1
Pages
79-85
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.55.1.79-85.1985
PMC
PMC254900
OpenAlex
W1493165726
Cited by
40
References
38
Citations by year
2025: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 2
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (CA27108)
  • National Institute of General Medical Sciences (GM 07310)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Mycology
Keywords
viral assembly, immature virus particles, provirus
MeSH terms
Animals, Avian Sarcoma Viruses, Cells, Cultured, Chickens, Chromosome Deletion, Microscopy, Electron, Molecular Weight, Morphogenesis, Mutation, Protein Precursors, Viral Proteins, Virion, Virus Replication, Gene Products, gag

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.