The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome
Open accessAbstract
We determined the complete nucleotide sequence of the human endogenous retrovirus genome HERV-K10 isolated as the sequence homologous to the Syrian hamster intracisternal A-particle (type A retrovirus) genome. HERV-K10 is 9,179 base pairs long with long terminal repeats of 968 base pairs at both ends; a sequence 290 base pairs long, however, was found to be deleted. It was concluded that a composite genome having the 290-base-pair fragment is the prototype HERV-K provirus gag (666 codons), protease (334 codons), pol (937 codons), and env (618 codons) genes. The size of the protease gene product of HERV-K is essentially the same as that of A- and D-type oncoviruses but nearly twice that of other retroviruses. A comparison of the deduced amino acid sequences encoded by the pol region showed HERV-K to be closely related to types A and D retroviruses and even more so to type B retrovirus. It was noted that the env gene product of HERV-K structurally resembles the mouse mammary tumor virus (type B retrovirus) env protein, and the possible expression of the HERV-K env gene in human breast cancer cells is discussed.
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Cites
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Self-citation
Cited by
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Metadata
- Authors
- Ono, M., Yasunaga, T., Miyata, T., & Ushikubo, H.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1986-11
- Volume
- 60
- Issue
- 2
- Pages
- 589-598
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1767157475
- Cited by
- 332
- References
- 34
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Ono, M., Yasunaga, T., Miyata, T., & Ushikubo, H. (1986). Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome. Journal of Virology. https://doi.org/10.1128/jvi.60.2.589-598.1986
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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