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Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice
Open accessAbstract
The outer membrane of the hepatitis B virus consists of host lipid and the hepatitis B virus major (p25, gp28), middle (gp33, gp36), and large (p39, gp42) envelope polypeptides. These polypeptides are encoded by a large open reading frame that contains three in-phase translation start codons and a shared termination signal. The influence of the large envelope polypeptide on the secretion of hepatitis B surface antigen (HBsAg) subviral particles in transgenic mice was examined. The major polypeptide is the dominant structural component of the HBsAg particles, which are readily secreted into the blood. A relative increase in production of the large envelope polypeptide compared with that of the major envelope polypeptide led to profound reduction of the HBsAg concentration in serum as a result of accumulation of both envelope polypeptides in a relatively insoluble compartment within the cell. We conclude that inhibition of HBsAg secretion is related to a hitherto unknown property of the pre-S-containing domain of the large envelope polypeptide.
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Cited by
Guidotti, L. G., Ando, K., Hobbs, M. V., Ishikawa, T., Runkel, L., Schreiber, R. D., & Chisari, F. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3764 · Cited by 412
Self-citationInflammation and the development of pancreatic cancer
Farrow, B., & Evers, B. M. (2002) · Surgical Oncology · doi:10.1016/s0960-7404(02)00015-4 · Cited by 338
Pinkert, C. A., Ornitz, D. M., Brinster, R. L., & Palmiter, R. D. (1987) · Genes & Development · doi:10.1101/gad.1.3.268 · Cited by 315
Self-citationHou, X., Hao, X., Zheng, M., Xu, C., Wang, J., Zhou, R., & Tian, Z. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.111 · Cited by 41
Metadata
- Authors
- Chisari, F. V., Filippi, P., McLachlan, A., Milich, D. R., Riggs, M., Lee, S., Palmiter, R. D., Pinkert, C. A., & Brinster, R. L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1986-12
- Volume
- 60
- Issue
- 3
- Pages
- 880-887
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1544473294
- Cited by
- 269
- References
- 0
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. https://app.cochat.ai/papers/10.1128/jvi.60.3.880-887.1986
- The paper
- Chisari, F. V., Filippi, P., McLachlan, A., Milich, D. R., Riggs, M., Lee, S., Palmiter, R. D., Pinkert, C. A., & Brinster, R. L. (1986). Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. Journal of Virology. https://doi.org/10.1128/jvi.60.3.880-887.1986
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
