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Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
Open accessAbstract
A population of Mus musculus subsp. musculus (Czech II), recently isolated from the wild, lack endogenous mouse mammary tumor virus (MMTV) proviral genomes. Some of these mice carry an infectious MMTV [designated MMTV (Czech II)] that is transmitted in the milk and is associated with mammary tumor development. This virus is distinct from laboratory strains of MMTV present in inbred mice. An MMTV (Czech II) genome was found within a 0.5-kilobase region of the cellular genome in five of 16 Czech II mammary tumors. MMTV insertion at this site activates expression of a 2.4-kilobase species of RNA from a previously silent cellular gene. This region of the cellular genome was designated int-3 since it is unrelated to the int-1 and int-2 loci. The int-3 locus does not appear to correspond to other proto-oncogenes but is well conserved among mammalian species.
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Citations
Cited by
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Metadata
- Authors
- Gallahan, D., & Callahan, R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1987-01
- Volume
- 61
- Issue
- 1
- Pages
- 66-74
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1518709728
- Cited by
- 205
- References
- 0
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. https://app.cochat.ai/papers/10.1128/jvi.61.1.66-74.1987
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- Gallahan, D., & Callahan, R. (1987). Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. Journal of Virology. https://doi.org/10.1128/jvi.61.1.66-74.1987
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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