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Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70
Abstract
We have investigated the biochemical properties of Xenopus laevis p53. With an in vitro binding assay, we can detect a specific association between X. laevis p53 and simian virus 40 large T antigen. Furthermore, X. laevis p53 expressed in monkey COS cells is stably associated with this viral antigen. Like mammalian p53, X. laevis p53 in complex with simian virus 40 large T antigen exhibits a 20-fold increase of its half-life. On the other hand, X. laevis p53 is unable to associate either in vivo or in vitro with adenovirus type 5 E1B 55-kilodalton protein. We show by an immunological technique that X. laevis p53 forms specific complexes with mammalian hsp72 and hsp73 heat shock proteins only at a temperature well above the optimal growth temperature for X. laevis. Our results suggest that the protein-binding properties of p53 are closely related to the functional activity of the protein.
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“This evolution goes along with increased sensitivity of the p53 DBD to structural stress compared with the more stable paralogs p63 and p73.”
From Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog (2022) · cites this paper as [26]
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Cited by
Zhang, Q., Balourdas, D.-I., Baron, B., Senitzki, A., Haran, T. E., Wiman, K. G., Soussi, T., & Joerger, A. C. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04653-8 · Cited by 14
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Metadata
- Authors
- Soussi, T., Caron de Fromentel, C., Stürzbecher, H. W., Ullrich, S., Jenkins, J., & May, P.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-09
- Volume
- 63
- Issue
- 9
- Pages
- 3894-3901
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 26
- References
- 0
- Language
- en
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- CoChat. (2026). Citation check: Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70. https://app.cochat.ai/papers/10.1128/jvi.63.9.3894-3901.1989
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- Soussi, T., Caron de Fromentel, C., Stürzbecher, H. W., Ullrich, S., Jenkins, J., & May, P. (1989). Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70. Journal of Virology. https://doi.org/10.1128/jvi.63.9.3894-3901.1989
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