The DOI matches its Crossref record.
Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions
Open accessAbstract
Sequences required for efficient packaging of human immunodeficiency virus type 1 (HIV-1) genome RNA into virus particles were identified. Deletion of 19 base pairs between the 5' long terminal repeat and the gag gene initiation codon of HIV-1 resulted in a virus markedly attenuated for replication in human T lymphocytes. The mutant virus was characterized by nearly wild-type ability to encode viral proteins and to produce virion particles. The mutant virions exhibited a significant reduction in the content of HIV-1-specific RNA. These results identify an important component of the HIV-1 packaging signal.
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Citations
Cited by
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499
Skripkin, E., Paillart, J. C., Marquet, R., Ehresmann, B., & Ehresmann, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4945 · Cited by 401
Paxton, W., Connor, R. I., & Landau, N. R. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7229-7237.1993 · Cited by 371
Metadata
- Authors
- Lever, A., Gottlinger, H., Haseltine, W., & Sodroski, J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-09
- Volume
- 63
- Issue
- 9
- Pages
- 4085-4087
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1551381216
- Cited by
- 375
- References
- 0
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Lever, A., Gottlinger, H., Haseltine, W., & Sodroski, J. (1989). Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions. Journal of Virology. https://doi.org/10.1128/jvi.63.9.4085-4087.1989
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
