Cited by 337Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchVirology and Viral Diseases

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Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells

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Dingwell, K S, Brunetti, C R, Hendricks, R L, Tang, Q, Tang, M, Rainbow, A J, Johnson, D C·1994·Journal of Virology

DOI 10.1128/jvi.68.2.834-845.1994PMC PMC236520

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Abstract

Herpes simplex virus (HSV) glycoproteins E and I (gE and gI) can act as a receptor for the Fc domain of immunoglobulin G (IgG). To examine the role of HSV IgG Fc receptor in viral pathogenesis, rabbits and mice were infected by the corneal route with HSV gE- or gI- mutants. Wild-type HSV-1 produced large dendritic lesions in the corneal epithelium and subsequent stromal disease leading to viral encephalitis, whereas gE- and gI- mutant viruses produced microscopic punctate or small dendritic lesions in the epithelium and no corneal disease or encephalitis. These differences were not related to the ability of the gE-gI oligomer to bind IgG because the differences were observed before the appearance of anti-HSV IgG and in mice, in which IgG binds to the Fc receptor poorly or not at all. Mutant viruses produced small plaques on monolayers of normal human fibroblasts and epithelial cells. Replication of gE- and gI- mutant viruses in human fibroblasts were normal, and the rates of entry of mutant and wild-type viruses into fibroblasts were similar; however, spread of gE- and gI- mutant viruses from cell to cell was significantly slower than that of wild-type HSV-1. In experiments in which fibroblast monolayers were infected with low multiplicities of virus and multiple rounds of infection occurred, the presence of neutralizing antibodies in the culture medium caused the yields of mutant viruses to drop dramatically, whereas there was a lesser effect on the production of wild-type HSV. It appears that cell-to-cell transmission of wild-type HSV-1 occurs by at least two mechanisms: (i) release of virus from cells and entry of extracellular virus into a neighboring cell and (ii) transfer of virus across cell junctions in a manner resistant to neutralizing antibodies. Our results suggest that gE- and gI- mutants are defective in the latter mechanism of spread, suggesting the possibility that the gE-gI complex facilitates virus transfer across cell junctions, a mode of spread which may predominate in some tissues. It is ironic that the gE-gI complex, usually considered an IgG Fc receptor, may, through its ability to mediate cell-to-cell spread, actually protect HSV from IgG in a manner different than previously thought.

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302
Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity
Herold, B. C., WuDunn, D., Soltys, N., & Spear, P. G. (1991) · Journal of Virology · doi:10.1128/jvi.65.3.1090-1098.1991 · Cited by 571
Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1
McGeoch, D. J., Dolan, A., Donald, S., & Rixon, F. J. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90320-1 · Cited by 521
A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells
Ligas, M. W., & Johnson, D. C. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1486-1494.1988 · Cited by 510
Self-citation
Proteins Specified by Herpes Simplex Virus XII. The Virion Polypeptides of Type 1 Strains
Heine, J. W., Honess, R. W., Cassai, E., & Roizman, B. (1974) · Journal of Virology · doi:10.1128/jvi.14.3.640-651.1974 · Cited by 501
Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion
Cai, W., Gu, B., & Person, S. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2596-2604.1988 · Cited by 476
Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted
Forrester, A., Farrell, H. E., Wilkinson, G. W. G., Kaye, J. F., Davis-Poynter, N. J., & Minson, T. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.341-348.1992 · Cited by 389
Genetic Studies with Herpes Simplex Virus Type 1. The Isolation of Temperature-sensitive Mutants, their Arrangement into Complementation Groups and Recombination Analysis Leading to a Linkage Map
Brown, S. M., Ritchie, D. A., & Subak-Sharpe, J. H. (1973) · Journal of General Virology · doi:10.1099/0022-1317-18-3-329 · Cited by 387
Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells
Friedman, H. M., Cohen, G. H., Eisenberg, R. J., Seidel, C., & Cines, D. B. (1984) · Nature · doi:10.1038/309633a0 · Cited by 384

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Authors: Dingwell, K. S., Brunetti, C. R., Hendricks, R. L., Tang, Q., Tang, M., Rainbow, A. J., & Johnson, D. C.
Affiliations: McMaster University (CA)
ORCID: Brunetti, C R
Hendricks, R L
Tang, M
Johnson, D C
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1994-02
Volume: 68
Issue: 2
Pages: 834-845
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.68.2.834-845.1994
PMC: PMC236520
OpenAlex: W2169191388
Cited by: 337
References: 64
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 6
FWCI: 13.71
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: herpes simplex virus type 1, glycoprotein E, glycoprotein I, cell-to-cell transmission, IgG Fc receptor, corneal infection, viral encephalitis, cell junctions, neutralizing antibodies, viral pathogenesis, fibroblasts, epithelial cells
MeSH terms: Animals, Biological Transport, Cell Communication, Cells, Cultured, Female, Fibroblasts, Humans, Intercellular Junctions, Viral Plaque Assay, Receptors, Fc, Viral Envelope Proteins, Virulence, Mutagenesis, Herpesvirus 1, Human, Mice

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Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells

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