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Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1
Open accessAbstract
The condition of a chimpanzee (C499) infected with three different isolates of human immunodeficiency virus type 1 (HIV-1) for over 10 years progressed to AIDS. Disease development in this animal was characterized by (i) a decline in CD4+ cells over the last 3 years; (ii) an increase in viral loads in plasma; (iii) the presence of a virus, termed HIV-1JC, which is cytopathic for chimpanzee peripheral blood mononuclear cells; and (iv) the presence of an opportunistic infection and blood dyscrasias. Genetic analysis of the V1-V2 region of the envelope gene of HIV-1JC showed that the virus present in C499 was significantly divergent from all inoculating viruses (> or = 16% divergent at the amino acid level) and was suggestive of a large quasispecies. Blood from C499 transfused into an uninfected chimpanzee (C455) induced a rapid and sustained CD4+-cell decline in the latter animal, concomitant with high plasma viral loads. These results show that HIV-1 can induce AIDS in chimpanzees and suggest that long-term passage of HIV-1 in chimpanzees can result in the development of a more pathogenic virus.
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Citations
Cited by
Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution
Fortna, A., Kim, Y., MacLaren, E., Marshall, K., Hahn, G., Meltesen, L., Brenton, M., Hink, R., Burgers, S., Hernandez-Boussard, T., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020207 · Cited by 276
Loss of Siglec expression on T lymphocytes during human evolution
Nguyen, D. H., Hurtado-Ziola, N., Gagneux, P., & Varki, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510484103 · Cited by 204
Marzio, G., Verhoef, K., Vink, M., & Berkhout, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111031498 · Cited by 81
An Assessment of the Role of Chimpanzees in AIDS Vaccine Research
Bailey, J. (2008) · Alternatives to Laboratory Animals · doi:10.1177/026119290803600403 · Cited by 49
Metadata
- Authors
- Novembre, F. J., Saucier, M., Anderson, D. C., Klumpp, S. A., O'Neil, S. P., Brown, C. R., Hart, C. E., Guenthner, P. C., Swenson, R. B., & McClure, H. M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1997-05
- Volume
- 71
- Issue
- 5
- Pages
- 4086-4091
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1563485932
- Cited by
- 205
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Novembre, F. J., Saucier, M., Anderson, D. C., Klumpp, S. A., O'Neil, S. P., Brown, C. R., Hart, C. E., Guenthner, P. C., Swenson, R. B., & McClure, H. M. (1997). Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1. Journal of Virology. https://doi.org/10.1128/jvi.71.5.4086-4091.1997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
