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Physiological Knockout of the Envelope Gene of the Single-Copy ERV-3 Human Endogenous Retrovirus in a Fraction of the Caucasian Population
Open accessAbstract
ERV-3 is an evolutionarily conserved single-copy human endogenous retrovirus with a coding envelope gene potentially involved in important placental functions. We have investigated the sequence variability of this gene among 150 unrelated Caucasian individuals and found eight polymorphic sites. One of them corresponds to the introduction of a stop codon resulting in the production of a severely truncated ERV-3 envelope protein lacking both the fusion peptide and the immunosuppressive domain of the protein. The stop codon is observed in a homozygous state in approximately 1% of Caucasian individuals without evidence for counterselection, thus precluding the involvement of any essential function of the gene in placental implantation and development. This natural knockout provides a mean to investigate other potential roles for this otherwise highly conserved gene.
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“For example, an early candidate for a syncytin-like role could be excluded by examination of a large number of human sequences 92.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [92]
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Research works printed but not linked: 17
- 10.1111/1523-1747.ep12329612 · DOI
- 10.1006/viro.1993.1556 · DOI
- 10.1002/bies.950090603 · DOI
- 10.1016/0042-6822(85)90147-3 · DOI
- 10.1016/S0092-8674(00)80338-4 · DOI · Paper page
- 10.1002/ijc.2910410310 · DOI
- 10.1096/fasebj.6.8.1592206 · DOI
- 10.3109/03009739409179354 · DOI
- Li J.-M. Fan W. S. Horsfall A. C. Anderson A. C. Rigby S. Larsson E. Venables P. J. W. The expression of human endogenous retrovirus-3 in fetal cardiac tissue and antibodies in congenital heart block.Clin. Exp. Immunol. 104 1996 388 393
- 10.1073/pnas.93.11.5177 · DOI
- 10.1016/0042-6822(84)90347-7 · DOI
- 10.1016/1040-8428(93)90009-S · DOI
- 10.3109/08916939608995334 · DOI
- 10.1016/0042-6822(91)90590-8 · DOI
- 10.1128/CMR.9.1.72 · DOI
- 10.1006/viro.1995.1442 · DOI
- Wilkinson D. A. Mager D. L. Leong J.-A. C. Endogenous human retroviruses 465–535.The Retroviridae. Levy J. A. 1994 Plenum Press New York N.Y · DOI
Cited by
Effects of Retroviruses on Host Genome Function
Jern, P., & Coffin, J. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091501 · Cited by 499
Dupressoir, A., Lavialle, C., & Heidmann, T. (2012) · Placenta · doi:10.1016/j.placenta.2012.05.005 · Cited by 362
Self-citationMangeney, M., Renard, M., Schlecht-Louf, G., Bouallaga, I., Heidmann, O., Letzelter, C., Richaud, A., Ducos, B., & Heidmann, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707873105 · Cited by 327
Self-citationEndogenous retroviruses in the human genome sequence.
(2001) · Genome biology · doi:10.1186/gb-2001-2-6-reviews1017 · Cited by 317
The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties
Mangeney, M., de Parseval, N., Thomas, G., & Heidmann, T. (2001) · Journal of General Virology · doi:10.1099/0022-1317-82-10-2515 · Cited by 159
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Metadata
- Authors
- de Parseval, N., & Heidmann, T.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- <!--label omitted: 1-->Unité des Rétrovirus Endogènes et Eléments Retroı̈des des Eucaryotes Supérieurs, CNRS UMR 1573, Institut Gustave Roussy, 94805 Villejuif Cedex, France
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1998-04
- Volume
- 72
- Issue
- 4
- Pages
- 3442-3445
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC109847
- OpenAlex
- W2119322510
- Cited by
- 95
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 3
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- human endogenous retroviruses, env gene, stop codon, polymorphism, Caucasian population, placental function, fusion peptide, sequence variation
- MeSH terms
- Base Sequence, DNA, Viral, Female, Humans, Male, Molecular Sequence Data, Pedigree, Polymorphism, Genetic, Population, Retroviridae, Genes, env, Gene Deletion, Codon, Terminator, White People
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- CoChat. (2026). Citation check: Physiological Knockout of the Envelope Gene of the Single-Copy ERV-3 Human Endogenous Retrovirus in a Fraction of the Caucasian Population. https://app.cochat.ai/papers/10.1128/jvi.72.4.3442-3445.1998
- The paper
- de Parseval, N., & Heidmann, T. (1998). Physiological Knockout of the Envelope Gene of the Single-Copy ERV-3 Human Endogenous Retrovirus in a Fraction of the Caucasian Population. Journal of Virology. https://doi.org/10.1128/jvi.72.4.3442-3445.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
