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Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
Open accessAbstract
We investigated the role of human CRM1 (hCRM1) (exportin 1) in the function of Rex protein encoded by human T-cell leukemia virus type 1. hCRM1 promoted the export of Rex protein from the nucleus to the cytoplasm. A Rex protein with a mutation in the activation domain, RexM90, lost both the ability to bind to hCRM1 and the ability to multimerize. The overexpression of hCRM1 complemented the functional defects of RexM64, which contains a mutation in the multimerization domain of Rex. A dominant-negative mutant of Rex which sequesters cofactors of Rex abrogated multimerization as well as the activity of the wild-type Rex protein. These two functions were simultaneously restored by the overexpression of hCRM1. Taken together, these results suggest that hCRM1 plays important roles in the multimerization and export of Rex protein.
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“Following the interaction between Rex and RexRE, RNAs are stabilized, splicing is inhibited, and they are subsequently exported out of the nucleus via a CRM1-dependent cellular pathway (Fig. 9) (Ahmed et al. 1990, Grassmann et al. 1991, Hakata et al. 1998, 2001, 2003, Nakano and Watanabe 2012).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Hakata et al. 1998
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Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication
Jehad, M. A., Ali, L. M., Pillai, V. N., Prabhu, S. G., Mustafa, F., & Rizvi, T. A. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf066 · Cited by 5
“9 ) (Ahmed et al. 1990 , Grassmann et al. 1991 , Hakata et al. 1998 , 2001 , 2003 , Nakano and Watanabe 2012 ).”
Metadata
- Authors
- Hakata, Y., Umemoto, T., Matsushita, S., & Shida, H.
- Affiliations
- Kyoto University (JP)
- Kumamoto University (JP)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1998-08
- Volume
- 72
- Issue
- 8
- Pages
- 6602-6607
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC109841
- OpenAlex
- W1542993021
- Cited by
- 74
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 4
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- CRM1, Rex protein, HTLV-1, nuclear export, protein oligomerization, transactivation domain, dominant-negative mutant, complementation
- MeSH terms
- Exportin 1 Protein, Biological Transport, Carrier Proteins, HeLa Cells, Humans, Nuclear Proteins, Recombinant Fusion Proteins, Human T-lymphotropic virus 1, Mutagenesis, Gene Products, rex, Receptors, Cytoplasmic and Nuclear, Karyopherins
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- CoChat. (2026). Citation check: Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1. https://app.cochat.ai/papers/10.1128/jvi.72.8.6602-6607.1998
- The paper
- Hakata, Y., Umemoto, T., Matsushita, S., & Shida, H. (1998). Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1. Journal of Virology. https://doi.org/10.1128/jvi.72.8.6602-6607.1998
