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Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection
Open accessAbstract
To understand the high variability of the asymptomatic interval between primary human immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied the evolution of the C2-V5 region of the HIV-1 env gene and of T-cell subsets in nine men with a moderate or slow rate of disease progression. They were monitored from the time of seroconversion for a period of 6 to 12 years until the development of advanced disease in seven men. Based on the analysis of viral divergence from the founder strain, viral population diversity within sequential time points, and the outgrowth of viruses capable of utilizing the CXCR4 receptor (X4 viruses), the existence of three distinct phases within the asymptomatic interval is suggested: an early phase of variable duration during which linear increases (∼1% per year) in both divergence and diversity were observed; an intermediate phase lasting an average of 1.8 years, characterized by a continued increase in divergence but with stabilization or decline in diversity; and a late phase characterized by a slowdown or stabilization of divergence and continued stability or decline in diversity. X4 variants emerged around the time of the early- to intermediate-phase transition and then achieved peak representation and began a decline around the transition between the intermediate and late phases. The late-phase transition was also associated with failure of T-cell homeostasis (defined by a downward inflection in CD3+T cells) and decline of CD4+T cells to ≤200 cells/μl. The strength of these temporal associations between viral divergence and diversity, viral coreceptor specificity, and T-cell homeostasis and subset composition supports the concept that the phases described represent a consistent pattern of viral evolution during the course of HIV-1 infection in moderate progressors. Recognition of this pattern may help explain previous conflicting data on the relationship between viral evolution and disease progression and may provide a useful framework for evaluating immune damage and recovery in untreated and treated HIV-1 infections.
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“If many calibration dates are available - for example, if a series of samples from a single infected patient 62 or a collection of archived samples 63 is available - it becomes possible to test the constancy of rates across the viral phylogeny.”
From The modern molecular clock (2003) · cites this paper as [62]
Citations
Cites
Kimura, M. (1980) · Journal of Molecular Evolution · doi:10.1007/bf01731581 · Cited by 29,778
PHYLIP-Phylogeny inference package (Version 3.2)
Felsenstein, J. (1989) · Cladistics · Cited by 17,682
Castro, K. G., Ward, J., Slutsker, L., Buehler, J. W., Jaffe, H. W., Berkelman, R. L., & Curran, J. W. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.4.802 · Cited by 4,347
Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma
Mellors, J. W., Rinaldo, C. R., Gupta, P., White, R. M., Todd, J. A., & Kingsley, L. (1996) · Science · doi:10.1126/science.272.5265.1167 · Cited by 2,658
Self-citationKoup, R. A., Safrit, J. T., Cao, Y., Andrews, C. A., McLeod, G. X., Borkowsky, W., Farthing, C., & Ho, D. D. (1994) · Journal of Virology · doi:10.1128/jvi.68.7.4650-4655.1994 · Cited by 2,494
Multiple Regression and Correlation Extensions of the Mantel Test of Matrix Correspondence
Smouse, P. E., Long, J. C., & Sokal, R. R. (1986) · Systematic Zoology · doi:10.2307/2413122 · Cited by 2,163
Plasma Viral Load and CD4+ Lymphocytes as Prognostic Markers of HIV-1 Infection
Mellors, J. W., Munoz, A., Giorgi, J. V., Margolick, J. B., Tassoni, C. J., Gupta, P., Kingsley, L. A., Todd, J. A., Saah, A. J., Detels, R., et al. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-12-199706150-00003 · Cited by 2,063
Self-citationThe lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953
Decay characteristics of HIV-1-infected compartments during combination therapy
Perelson, A. S., Essunger, P., Cao, Y., Vesanen, M., Hurley, A., Saksela, K., Markowitz, M. H., & Ho, D. D. (1997) · Nature · doi:10.1038/387188a0 · Cited by 1,861
Autran, B., Carcelain, G., Li, T., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debré, P., & Leibowitch, J. (1997) · Science · doi:10.1126/science.277.5322.112 · Cited by 1,786
Research works printed but not linked: 3
- Kuiken C. L. Korber B. Epidemiological significance of intra- and inter-person variation of HIV-1.AIDS 8 1994 S73 S83
- Mantel N. The detection of disease clustering and a generalized regression approach.Cancer Res. 27 1967 209 220
- Pelletier E. Wain-Hobson S. AIDS is not caused by the extreme genetic variability of HIV.J. NIH Res. 8 1996 45 48
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López-Bueno, A., Segovia, J. C., Bueren, J. A., O’Sullivan, M. G., Wang, F., Tattersall, P. J., & Almendral, J. M. (2007) · Journal of Virology · doi:10.1128/jvi.01692-07 · Cited by 18
Gupta, R. M., Prasad, V. V. S. P., Rai, A., & Seth, P. (2005) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2005.21.1066 · Cited by 18
Templeton, A. R., Reichert, R. A., Weisstein, A. E., Yu, X.-F., & Markham, R. B. (2004) · Genetics · doi:10.1534/genetics.103.023945 · Cited by 18
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Skar, H., Hedskog, C., & Albert, J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06128.x · Cited by 17
Krakoff, E., Gagne, R. B., VandeWoude, S., & Carver, S. (2019) · Journal of Virology · doi:10.1128/jvi.00538-19 · Cited by 17
Omondi, F. H., Sudderuddin, H., Shahid, A., Kinloch, N. N., Jones, B. R., Miller, R. L., Tsai, O., MacMillan, D., Piechocka‐Trocha, A., Brockman, M. A., et al. (2021) · mBio · doi:10.1128/mbio.02490-21 · Cited by 18
Sunshine, J. E., Kim, M., Carlson, J. M., Heckerman, D. E., Czartoski, J., Migueles, S. A., Maenza, J. R., McElrath, M. J., Mullins, J. I., & Frahm, N. (2013) · Journal of Virology · doi:10.1128/jvi.02361-13 · Cited by 17
Self-citationKesturu, G. S., Colleton, B. A., Liu, Y., Heath, L., Shaikh, O. S., Rinaldo, C. R., & Shankarappa, R. (2006) · Virology · doi:10.1016/j.virol.2005.11.055 · Cited by 17
Self-citationGray, L. R., Churchill, M. J., Sterjovski, J., Witlox, K. J., Learmont, J. C., Sullivan, J. S., Wesselingh, S. L., Gabuzda, D. H., Cunningham, A. L., McPhee, D. A., et al. (2007) · Virology Journal · doi:10.1186/1743-422x-4-75 · Cited by 17
Romero-Severson, E. O., Bulla, I., Hengartner, N., Bártolo, I., Abecasis, A. B., Azevedo‐Pereira, J. M., Taveira, N., & Leitner, T. (2017) · Genetics · doi:10.1534/genetics.117.300284 · Cited by 17
Yaseen, M. M., Abuharfeil, N. M., Alqudah, M. A. Y., & Yaseen, M. M. (2017) · Viral Immunology · doi:10.1089/vim.2017.0065 · Cited by 17
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Martı́nez, M. Á., Martrus, G., Capel, E., Parera, M., Franco, S., & Nevot, M. (2012) · Springer eBooks · doi:10.1007/978-94-007-4899-6_2 · Cited by 17
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Wagner, A. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2016.10.017 · Cited by 19
Cabrera-Rodríguez, R., Robert-Hebmann, V., Marfil, S., Pernas, M., Marrero‐Hernández, S., Cabrera, C., Urrea, V., Casado, C., Olivares, I., Márquez-Arce, D., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42075-3 · Cited by 17
Bagnarelli, P., Fiorelli, L., Vecchi, M., Monachetti, A., Menzo, S., & Clementi, M. (2003) · Virology · doi:10.1016/s0042-6822(02)00077-6 · Cited by 17
Roberts, F. S. (2003) · Society for Industrial and Applied Mathematics eBooks · doi:10.1137/1.9780898717518.ch1 · Cited by 17
Ito, Y., Grivel, J., Chen, S., Kiselyeva, Y., Reichelderfer, P. S., & Margolis, L. B. (2004) · The Journal of Infectious Diseases · doi:10.1086/381153 · Cited by 17
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Romero, E. V., & Feder, A. F. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad260 · Cited by 16
Shahid, A., MacLennan, S., Jones, B. R., Sudderuddin, H., Dang, Z., Cobarrubias, K. D., Duncan, M. C., Kinloch, N. N., Dapp, M. J., Archin, N. M., et al. (2024) · Journal of Virology · doi:10.1128/jvi.01655-23 · Cited by 16
Self-citationLamers, S. L., Nolan, D. J., Magalis, B. R., Fogel, G. B., McGrath, M. S., Burdo, T. H., Autissier, P., Williams, K. C., Goodenow, M. M., & Salemi, M. (2015) · Journal of Virology · doi:10.1128/jvi.01010-15 · Cited by 16
Samman, A., McMonagle, E. L., Logan, N. A., Willett, B. J., Biek, R., & Hosie, M. J. (2011) · Veterinary Microbiology · doi:10.1016/j.vetmic.2011.01.027 · Cited by 16
Shiino, T., Hattori, J., Yokomaku, Y., Iwatani, Y., Sugiura, W., & Japanese Drug Resistance HIV-1 Surveillance Network (2014) · PLoS ONE · doi:10.1371/journal.pone.0102633 · Cited by 16
Metadata
- Authors
- Shankarappa, R., Margolick, J. B., Gange, S. J., Rodrigo, A. G., Upchurch, D., Farzadegan, H., Gupta, P., Rinaldo, C. R., Learn, G. H., He, X., Huang, X.-L., & Mullins, J. I.
- Affiliations
- University of Washington (US)
- <!--label omitted: 2-->Departments of Molecular Microbiology and Immunology2 and of
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1999-12
- Volume
- 73
- Issue
- 12
- Pages
- 10489-10502
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC113104
- OpenAlex
- W2126515754
- Cited by
- 926
- References
- 84
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 14 · 2023: 19 · 2022: 16 · 2021: 13 · 2020: 22 · 2019: 33 · 2018: 24 · 2017: 33 · 2016: 31 · 2015: 35 · 2014: 36 · 2013: 50 · 2012: 57
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai034783-05, 5r01ai032885-06)
- National Institute of Allergy and Infectious Diseases (AI-34783, AI37984, U01AI035040, U01AI037984, U01AI035041, AI-32885, U01AI035039, U01AI035042, P30AI027757)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- HIV-1, viral evolution, disease progression, asymptomatic HIV infection, HIV-1 env gene, viral divergence, viral population diversity, CXCR4, T cell homeostasis, CD4+ T cells, CD3+ T cells
- MeSH terms
- Base Sequence, DNA, Viral, Humans, Male, Molecular Sequence Data, Prospective Studies, HIV-1, HIV Infections, Gene Products, env, Disease Progression, Evolution, Molecular
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