Cited by 160Viral Infections and Immunology ResearchRNA and protein synthesis mechanismsVirology and Viral Diseases

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Dual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence

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Gromeier, Matthias, Bossert, Birgit, Arita, Mineo, Nomoto, Akio, Wimmer, Eckard·1999·Journal of Virology

DOI 10.1128/jvi.73.2.958-964.1999PMC PMC103915

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Abstract

In the human central nervous system, susceptibility to poliovirus (PV) infection is largely confined to a specific subpopulation of neuronal cells. PV tropism is likely to be determined by cell-external components such as the PV receptor CD155, as well as cell-internal constraints such as the availability of a suitable microenvironment for virus propagation. We reported previously that the exchange of the cognate internal ribosomal entry site (IRES) within the 5′ nontranslated region of PV with its counterpart from human rhinovirus type 2 (HRV2) can eliminate the neuropathogenic phenotype in a transgenic mouse model for poliomyelitis without diminishing the growth properties in HeLa cells. We now show that attenuation of neurovirulence of PV/HRV2 chimeras is not confined to CD155 transgenic mice but is evident also after intraspinal inoculation into Cynomolgus monkeys. We have dissected the PV and HRV2 IRES elements to determine those structures responsible for neurovirulence (or attenuation) of these chimeric viruses. We report that two adjacent stem loop structures within the IRES cooperatively determine neuropathogenicity.

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Authors: Gromeier, M., Bossert, B., Arita, M., Nomoto, A., & Wimmer, E.
Affiliations: State University of New York (US)
Institute of Medical Science, The University of Tokyo (JP)
ORCID: Gromeier, Matthias
Wimmer, Eckard
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1999-02
Volume: 73
Issue: 2
Pages: 958-964
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.73.2.958-964.1999
PMC: PMC103915
OpenAlex: W1529709430
Cited by: 160
References: 45
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 4 · 2014: 14 · 2013: 5 · 2012: 4
FWCI: 7.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI032100, R01AI039485)
Topics: Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: poliovirus, internal ribosome entry site, neurovirulence, stem-loop structure, CD155, 5' untranslated region, neurotropism, viral attenuation, transgenic mouse model, Macaca fascicularis
MeSH terms: Animals, Base Sequence, HeLa Cells, Humans, Macaca fascicularis, Membrane Proteins, Mice, Transgenic, Molecular Sequence Data, Neurons, Nucleic Acid Conformation, Receptors, Virus, RNA, Viral, Virulence, Poliovirus, 5' Untranslated Regions, Mice

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Dual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence

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