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Binding of Rabbit Hemorrhagic Disease Virus to Antigens of the ABH Histo-Blood Group Family
Open accessAbstract
The ability of rabbit hemorrhagic disease virus to agglutinate human erythrocytes and to attach to rabbit epithelial cells of the upper respiratory and digestive tracts was shown to depend on the presence of ABH blood group antigens. Indeed, agglutination was inhibited by saliva from secretor individuals but not from nonsecretors, the latter being devoid of H antigen. In addition, erythrocytes of the rare Bombay phenotype, which completely lack ABH antigens, were not agglutinated. Native viral particles from extracts of infected rabbit liver as well as virus-like particles from the recombinant virus capsid protein specifically bound to synthetic A and H type 2 blood group oligosaccharides. Both types of particles could attach to adult rabbit epithelial cells of the upper respiratory and digestive tracts. This binding paralleled that of anti-H type 2 blood group reagents and was inhibited by the H type 2-specific lectin UEA-I and polyacrylamide-conjugated H type 2 trisaccharide. Young rabbit tissues were almost devoid of A and H type 2 antigens, and only very weak binding of virus particles could be obtained on these tissues.
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“while RHDV and human noroviruses bind histo-blood group antigens – complex carbohydrates linked to glycoproteins or glycolipids on the surface of erythrocytes and mucosal epithelial cells [40–42].”
From Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures (2017) · cites this paper as [42]
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Christensen, N. D., & Peng, X. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-380920-9.00007-9 · Cited by 7
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Lerrer, B., Lesman-Movshovich, E., & Gilboa-Garber, N. (2005) · Current Microbiology · doi:10.1007/s00284-005-4571-0 · Cited by 6
“The H-2 epitopes were recently reported to be able to block some infectious agents whose adhesins are strictly specific to the H-2 epitope [22, 23], and consequently ‘‘secretor’’ status was suggested to be advantageous for resisting those infections.”
BackgroundPendu, J. L., Rydell, G., Nasir, W., & Larson, G. (2016) · doi:10.1016/b978-0-12-802241-2.00018-3 · Cited by 6
Tokarz–Deptuła, B., Kulus, J., Baraniecki, Ł., Stosik, M. P., & Deptuła, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105342 · Cited by 8
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Wu, M.-S., Chen, M., Qiu, R., Ge, L., Fan, Z., Hu, B., Wei, H., Li, Y.-M., Wang, F., & Song, Y.-H. (2024) · Transboundary and Emerging Diseases · doi:10.1155/tbed/3881457 · Cited by 5
“Currently, reverse transcription-polymerase chain reaction (RT-PCR) [9], fl uorescence quantitative PCR [10, 11], haemag-glutination test [12], enzyme linked immunosorbent assay (ELISA) [13, 14], and many other detection methods are available.”
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Stomach expression of histo-blood group antigens A and B in some vertebrates
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“RHDV is thought to gain entry into the host via the upper respiratory or digestive tracts by binding to the carbohydrate moieties of histo-blood group antigens (HBGAs) displayed on epithelial cells [23, 24].”
Krejmer-Rąbalska, M., Peplińska, M., Szewczyk, B., & FITZNER, A. (2024) · Journal of Veterinary Research · doi:10.2478/jvetres-2024-0019 · Cited by 2
“This is generally consistent with the ability of all pathogenic RHDVs (except the rare HA-negative strains or samples containing degraded capsid protein) to agglutinate human erythrocytes and with the low reactivity in the HA of native EBHSV strains (8, 10, 33, 35).”
ResultViral Disease in Lagomorphs: A Molecular Perspective
Dalton, K. P., Podadera, A., Martín-Alonso, J. M., Sanz, I. C., Rodríguez, Á. L. Á., Casais, R., & Parra, F. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98272 · Cited by 2
Schwensow, N. (2012) · The Open Immunology Journal · doi:10.2174/1874226201205010020 · Cited by 2
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“RHDV has been shown to bind to histo-blood group antigens expressed on the surface of respiratory and digestive tract epithelial cells (Ruvoën-Clouet et al., 2000).”
Background[Interaction between noroviruses and human histo-blood group antigens].
Shirato-Horikoshi, H., & Takeda, N. (2007) · Uirusu · doi:10.2222/jsv.57.181 · Cited by 2
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“Ruvoën-Clouet et al. [44] suggested that this might be because RHDV binds to ABH blood group antigens of rabbit epithelial cells of the upper respiratory tract, but the tissues of very young rabbits are almost devoid of A and H type 2 antigens, leading to the very weak binding of virus particles…”
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“In clinical sciences, however, it is assumed that haemagglutination capacity of viruses is a decisive element for their pathogenicity (Ruvoén-Clouet et al. 2000), which was also confirmed for RHDV by Capucci et al. (1998); hence, it was assumed that HA+ RHDV strains should cause greater changes in…”
Backgroundvan Beek, J., & Koopmans, M. (2013) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-780-6_03 · Cited by 1
Viral Hemorrhagic Fevers of Animals Caused by Double-Stranded RNA Viruses
Miller, M. M., Lagreid, W., Kuhn, J., Lewis, C., Loiacono, C. M., & White, D. M. (2015) · doi:10.1007/978-1-4939-2410-3_13 · Cited by 1
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Fathollahi, A., Fakhar, H. B., & Shaghaghi, B. (2024) · Access Microbiology · doi:10.1099/acmi.0.000544.v5
“B.A.O phenotypes [25–27].”
BackgroundHisto-Blood Group Antigens: the Potential Receptor for the Rotaviruses
Duan, Z., Cao, Y., XiaoMan, S. U. N., & Guo, N. (2015) · Scientia Sinica Vitae · doi:10.1360/n052015-00039
Guiserix, M. (2009) · doi:10.70675/b6f26d4aze023z47e0z813bzf81a37bd96fb
“C’est ce qui expliquerait la résistance des très jeunes lapins à la maladie hémorragique (Morisse et al., 1991; Ruvöen-Clouet et al., 2000; Guillon et al., 2009).”
Hsu, C. C. (2007) · doi:10.32469/10355/4790
“16 Initially, studies with rabbit hemorrhagic disease virus (RHDV), a calicivirus in the genus Lagovirus, showed the importance of the H antigen in viral attachment and binding to rabbit epithelial cells (198).”
Background
Metadata
- Authors
- Ruvoën-Clouet, N., Ganière, J. P., André-Fontaine, G., Blanchard, D., & Le Pendu, J.
- Affiliations
- <!--label omitted: 1-->Unité de Pathologie Infectieuse, Ecole Nationale Vétérinaire, 44307 Nantes cedex 03,1
- Oniris (FR)
- <!--label omitted: 2-->Etablissement de Transfusion Sanguine, Pays de la Loire, 44011 Nantes cedex 01,2 and
- <!--label omitted: 3-->INSERM U419, Institut de Biologie, 44093 Nantes,3 France
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-12-15
- Volume
- 74
- Issue
- 24
- Pages
- 11950-11954
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC112478
- OpenAlex
- W2083189047
- Cited by
- 160
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 10 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 15 · 2013: 9 · 2012: 6
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- rabbit hemorrhagic disease virus, ABH blood group antigens, H antigen, A antigen, viral attachment, hemagglutination, secretor status, Bombay phenotype, virus-like particles, recombinant capsid protein, UEA-I lectin, upper respiratory tract, gastrointestinal tract
- MeSH terms
- ABO Blood-Group System, Adult, Animals, Erythrocytes, Humans, Rabbits, Receptors, Virus, Hemorrhagic Disease Virus, Rabbit
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