Direct Activation of Innate and Antigen-Presenting Functions of Microglia following Infection with Theiler's Virus

Olson, Julie K.; Girvin, Ann M.; Miller, Stephen D.

doi:10.1128/jvi.75.20.9780-9789.2001

Direct Activation of Innate and Antigen-Presenting Functions of Microglia following Infection with Theiler's Virus

Microglia are resident central nervous system (CNS) macrophages. Theiler's murine encephalomyelitis virus (TMEV) infection of SJL/J mice causes persistent infection of CNS microglia, leading to the development of a chronic-progressive CD4+T-cell-mediated autoimmune demyelinating disease. We asked…