The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Human Immunodeficiency Virus Type 1 Entry into Macrophages Mediated by Macropinocytosis
Open accessAbstract
Whereas human immunodeficiency virus (HIV) infects various cell types by fusion at the plasma membrane, we observed a different entry route in human primary macrophages, in which macropinocytosis is active. Shortly after exposure of macrophages to HIV-1 and irrespective of viral envelope-receptor interactions, particles were visible in intracellular vesicles, which were identified as macropinosomes. Most virions appeared subsequently degraded. However, fusion leading to capsid release in the cytosol and productive infection could take place inside vesicles when particles were properly enveloped. These observations provide new insights into HIV-1 interactions with a cell target relevant to pathogenesis. They may have implications for the design of soluble inhibitors aimed at interfering with the fusion or entry processes.
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Cites
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Cited by
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Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
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Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis
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HIV‐1 DNA Flap formation promotes uncoating of the pre‐integration complex at the nuclear pore
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Metadata
- Authors
- Maréchal, V., Prevost, M.-C., Petit, C., Perret, E., Heard, J.-M., & Schwartz, O.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2001-11-15
- Volume
- 75
- Issue
- 22
- Pages
- 11166-11177
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1995045410
- Cited by
- 290
- References
- 50
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Human Immunodeficiency Virus Type 1 Entry into Macrophages Mediated by Macropinocytosis. https://app.cochat.ai/papers/10.1128/jvi.75.22.11166-11177.2001
- The paper
- Maréchal, V., Prevost, M.-C., Petit, C., Perret, E., Heard, J.-M., & Schwartz, O. (2001). Human Immunodeficiency Virus Type 1 Entry into Macrophages Mediated by Macropinocytosis. Journal of Virology. https://doi.org/10.1128/jvi.75.22.11166-11177.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
