The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Charting Latency Transcripts in Kaposi's Sarcoma-Associated Herpesvirus by Whole-Genome Real-Time Quantitative PCR
Open accessAbstract
The division into a latent or lytic life cycle is fundamental to all herpesviridae. In the case of Kaposi's sarcoma-associated herpesvirus (KSHV) (human herpesvirus 8), latent genes have been implicated in cell autonomous transformation, while certain lytic genes procure a tumor friendly milieu through paracrine mechanism. To query KSHV transcription, we devised and validated a high-throughput, high-specificity, high-sensitivity, real-time quantitative reverse transcription-PCR array. This novel methodology is applicable to many human pathogens. Its first use demonstrated that the mRNA levels for KSHV LANA, v-cyclin, and v-FLIP do not increase at any time after viral reactivation. The mRNA for LANA-2/vIRF-3 is similarly resistant to viral reactivation. In contrast, every other latent or lytic message was induced. Hence, LANA, v-FLIP, v-cyclin, and LANA-2 constitute a group of uniquely regulated transcripts in the KSHV genome.
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Cites
Predicting DNA duplex stability from the base sequence
Breslauer, K. J., Frank, R., Blöcker, H., & Marky, L. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3746 · Cited by 1,837
Cited by
Cai, X., Lu, S., Zhang, Z., Gonzalez, C. M., Damania, B., & Cullen, B. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408192102 · Cited by 586
KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine
Ganem, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40567 · Cited by 385
Krishnan, H. H., Naranatt, P. P., Smith, M. S., Zeng, L., Bloomer, C., & Chandran, B. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3601-3620.2004 · Cited by 314
Fujimuro, M., Wu, F. Y., apRhys, C., Kajumbula, H., Young, D. B., Hayward, G. S., & Hayward, S. D. (2003) · Nature Medicine · doi:10.1038/nm829 · Cited by 307
Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses
Speck, S. H., & Ganem, D. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.06.014 · Cited by 302
Metadata
- Authors
- Fakhari, F. D., & Dittmer, D. P.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2002-06-15
- Volume
- 76
- Issue
- 12
- Pages
- 6213-6223
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2113694619
- Cited by
- 210
- References
- 1
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Fakhari, F. D., & Dittmer, D. P. (2002). Charting Latency Transcripts in Kaposi's Sarcoma-Associated Herpesvirus by Whole-Genome Real-Time Quantitative PCR. Journal of Virology. https://doi.org/10.1128/jvi.76.12.6213-6223.2002
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