The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Severe CD4+T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy
Open accessAbstract
Gut-associated lymphoid tissue (GALT) harbors the majority of T lymphocytes in the body and is an important target for human immunodeficiency virus type 1 (HIV-1). We analyzed longitudinal jejunal biopsy samples from HIV-1-infected patients, during both primary and chronic stages of HIV-1 infection, prior to and following the initiation of highly active antiretroviral therapy (HAART) to determine the onset of CD4+T-cell depletion and the effect of HAART on the restoration of CD4+T cells in GALT. Severe depletion of intestinal CD4+T cells occurred during primary HIV-1 infection. Our results showed that the restoration of intestinal CD4+T cells following HAART in chronically HIV-1-infected patients was substantially delayed and incomplete. In contrast, initiation of HAART during early stages of infection resulted in near-complete restoration of intestinal CD4+T cells, despite the delay in comparison to peripheral blood CD4+T-cell recovery. DNA microarray analysis of gene expression profiles and flow-cytometric analysis of lymphocyte homing and cell proliferation markers demonstrated that cell trafficking to GALT and not local proliferation contributed to CD4+T-cell restoration. Evaluation of jejunal biopsy samples from long-term HIV-1-infected nonprogressors showed maintenance of normal CD4+T-cell levels in both GALT and peripheral blood. Our results demonstrate that near-complete restoration of mucosal immune system can be achieved by initiating HAART early in HIV-1 infection. Monitoring of the restoration and/or maintenance of CD4+T cells in GALT provides a more accurate assessment of the efficacy of antiviral host immune responses as well as HAART.
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“In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [18]
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“It is known that especially integrin a 4 b 7 -expressing cells are predominantly infected and depleted during the early infection phases, with a rather poor recovery during ART. 18,20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [18]
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Cites
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Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Brenchley, J. M., Schacker, T. W., Ruff, L. E., Price, D. A., Taylor, J. H., Beilman, G. J., Nguyen, P. L., Khoruts, A., Larson, M. C., Haase, A. T., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040874 · Cited by 1,836
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Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
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Metadata
- Authors
- Guadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S.
- Affiliations
- University of California, Davis (US)
- Departments of Medical Microbiology & Immunology
- The Permanente Medical Group Inc.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-11
- Volume
- 77
- Issue
- 21
- Pages
- 11708-11717
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC229357
- OpenAlex
- W2076120354
- Cited by
- 866
- References
- 24
- Citations by year
- 2026: 13 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 23 · 2021: 27 · 2020: 21 · 2019: 26 · 2018: 26 · 2017: 32 · 2016: 42 · 2015: 45 · 2014: 48 · 2013: 62 · 2012: 60
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 61297, R01DK061297)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Keywords
- HIV-1 infection, CD4+ T cell depletion, gut-associated lymphoid tissue, highly active antiretroviral therapy, CD4+ T cell recovery, jejunal biopsy, lymphocyte homing, nonprogressors, gene expression profiling, early treatment initiation
- MeSH terms
- Adult, Cell Movement, Chronic Disease, Female, Flow Cytometry, Humans, Immunohistochemistry, Jejunum, Lymphocyte Activation, Lymphoid Tissue, Male, Middle Aged, Time Factors, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, CD8-Positive T-Lymphocytes, CD4 Lymphocyte Count, Antiretroviral Therapy, Highly Active
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