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Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons
Open accessAbstract
Formation of a membrane-associated replication complex, composed of viral proteins, replicating RNA, and altered cellular membranes, is a characteristic feature of plus-strand RNA viruses. Here, we demonstrate the presence of a specific membrane alteration, designated the membranous web, that contains hepatitis C virus (HCV) nonstructural proteins, as well as viral plus-strand RNA, in Huh-7 cells harboring autonomously replicating subgenomic HCV RNAs. Metabolic labeling with 5-bromouridine 5′-triphosphate in the presence of actinomycin D revealed that the membranous web is the site of viral RNA synthesis and therefore represents the replication complex of HCV.
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Cited by
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Ao, X., Zou, L., & Wu, Y. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2013.187 · Cited by 411
Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
Friebe, P., Boudet, J., Simorre, J.-P., & Bartenschlager, R. (2005) · Journal of Virology · doi:10.1128/jvi.79.1.380-392.2005 · Cited by 371
Self-citationStructure and Function of the Membrane Anchor Domain of Hepatitis C Virus Nonstructural Protein 5A
Penin, F., Brass, V., Appel, N., Ramboarina, S., Montserret, R., Ficheux, D., Blum, H. E., Bartenschlager, R., & Moradpour, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404761200 · Cited by 301
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Metadata
- Authors
- Gosert, R., Egger, D., Lohmann, V., Bartenschlager, R., Blum, H. E., Bienz, K., & Moradpour, D.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-05
- Volume
- 77
- Issue
- 9
- Pages
- 5487-5492
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2110671968
- Cited by
- 635
- References
- 0
- FWCI
- 22.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Gosert, R., Egger, D., Lohmann, V., Bartenschlager, R., Blum, H. E., Bienz, K., & Moradpour, D. (2003). Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons. Journal of Virology. https://doi.org/10.1128/jvi.77.9.5487-5492.2003
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