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Cited by 98Viral-associated cancers and disordersCytomegalovirus and herpesvirus researchHerpesvirus Infections and Treatments

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Epstein-Barr Virus Latent Membrane Protein LMP-2A Is Sufficient for Transactivation of the Human Endogenous Retrovirus HERV-K18 Superantigen

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Sutkowski, Natalie, Chen, Gang, Calderon, German, Huber, Brigitte T.·2004·Journal of Virology
DOI 10.1128/jvi.78.14.7852-7860.2004PMC PMC434102
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Abstract

Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

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Crossref · 10.1128/jvi.78.14.7852-7860.2004

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  • Transcription of a copy of HERV-K18 can be induced by several stimuli that activate B cells, including EBV infection.

    “Owing to integration into the first intron of the CD48 gene, encoding a lymphocyte-expressed member of the CD2 subfamily of immunoglobulin-like receptors, transcription of a copy of HERV-K18 can be induced by several stimuli that activate B cells, including EBV infection 47,48.”

    From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [48]

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Metadata

Authors
Sutkowski, N., Chen, G., Calderon, G., & Huber, B. T.
Affiliations
Tufts University (US)
Corresponding author
Huber, Brigitte T.
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2004-07-15
Volume
78
Issue
14
Pages
7852-7860
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.78.14.7852-7860.2004
PMC
PMC434102
OpenAlex
W1970080989
Cited by
98
References
0
Citations by year
2025: 6 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 2
FWCI
2.09
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (K01CA095443)
  • National Institute of Allergy and Infectious Diseases (R37-AI14910, R37AI014910)
Topics
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Keywords
Epstein-Barr virus, latent membrane protein, superantigens, transcriptional activation, human endogenous retroviruses, T cell stimulation
MeSH terms
Animals, Cell Line, Herpesvirus 4, Human, Humans, Viral Envelope Proteins, Viral Matrix Proteins, Transcriptional Activation, Gene Expression Regulation, Viral, Virus Latency, Superantigens, Endogenous Retroviruses

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