The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection
Open accessAbstract
After the first attachment of virus to the cell surface through a primary receptor, efficient entry of virus requires the presence of a coreceptor. For adeno-associated virus type 2 (AAV2) infection, heparan sulfate proteoglycan is supposed as the primary receptor, and αvβ5 integrin and FGFR1 are reported to act as coreceptors. In this study, we were able to demonstrate that hepatocyte growth factor receptor, c-Met, is also a coreceptor for AAV2 infection. AAV2-mediated transgene analyses revealed that c-Met expression significantly up-regulated transgene expression without increasing AAV2 cell binding. Moreover, a viral overlay assay elucidated the physical interaction between AAV2 and the β subunit of c-Met. These data suggest that c-Met plays the role of coreceptor for AAV2 infection by facilitating AAV2 internalization into the cytoplasm.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The early steps of AAV infection involve attachment to a variety of cell surface receptors such as HSPG, FGFR, αvβ5 integrin, and hepatocyte growth factor receptor (c-Met) (Fig. 8I) (9, 25, 31, 39, 40), followed by clathrin-dependent endocytosis (Fig.8II).”
From Packaging Capacity of Adeno-Associated Virus Serotypes: Impact of Larger Genomes on Infectivity and Postentry Steps (2005) · cites this paper as [25]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt‐Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., & Finberg, R. W. (1997) · Science · doi:10.1126/science.275.5304.1320 · Cited by 3,102
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
Bottaro, D. P., Rubin, J. S., Faletto, D. L., Chan, A. M.-L., Kmiecik, T. E., Woude, G. F. V., & Aaronson, S. A. (1991) · Science · doi:10.1126/science.1846706 · Cited by 2,226
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
Wickham, T. J., Mathias, P., Cheresh, D. A., & Nemerow, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90231-e · Cited by 2,199
Summerford, C., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1438-1445.1998 · Cited by 1,409
Molecular cloning of a new transforming gene from a chemically transformed human cell line
Cooper, C. S., Park, M., Blair, D. G., Tainsky, M. A., Huebner, K., Croce, C. M., & Woude, G. F. V. (1984) · Nature · doi:10.1038/311029a0 · Cited by 1,000
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
Manno, C. S., Chew, A. J., Hutchison, S., Larson, P. J., Herzog, R. W., Arruda, V. R., Tai, S. J., Ragni, M. V., Thompson, A., Ozelo, M., et al. (2003) · Blood · doi:10.1182/blood-2002-10-3296 · Cited by 749
αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection
Summerford, C., Bartlett, J. S., & Samulski, R. J. (1999) · Nature Medicine · doi:10.1038/4768 · Cited by 711
Emerging Multipotent Aspects of Hepatocyte Growth Factor
Matsumoto, K., & Nakamura, T. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021283 · Cited by 666
Self-citationPurification and subunit structure of hepatocyte growth factor from rat platelets
Nakamura, T., Nawa, K., Ichihara, A., Kaise, N., & Nishino, T. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80475-1 · Cited by 548
Self-citationInfectious entry pathway of adeno-associated virus and adeno-associated virus vectors
Bartlett, J. S., Wilcher, R., & Samulski, R. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2777-2785.2000 · Cited by 532 · cited 1×
“by on January 25, 2010 jvi.asm.org Downloaded from ( 2 ).”
BackgroundExpression of the Met/HGF receptor in normal and neoplastic human tissues.
Renzo, M. F. D., Narsimhan, R. P., Olivero, M., Bretti, S., Giordano, S., Médico, E., Gaglia, P., Zara, P., & Comoglio, P. M. (1991) · PubMed · Cited by 474
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
Qing, K., Mah, C., Hansen, J., Zhou, S., Dwarki, V., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/4758 · Cited by 443
Mount, J. D., Herzog, R. W., Tillson, D. M., Goodman, S. A., Robinson, N., McCleland, M. L., Bellinger, D., Nichols, T. C., Arruda, V. R., Lothrop, C. D., et al. (2002) · Blood · doi:10.1182/blood.v99.8.2670 · Cited by 339
Adeno-associated viruses undergo substantial evolution in primates during natural infections
Gao, G., Alvira, M. R., Somanathan, S., Lü, Y., Vandenberghe, L. H., Rux, J. J., Calcedo, R., Sanmiguel, J. C., Abbas, Z., & Wilson, J. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937739100 · Cited by 323
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.
Rong, S., Bodescot, M., Blair, D. G., Dunn, J., Nakamura, T., Mizuno, K., Park, M., Chan, A. M.-L., Aaronson, S. A., & Woude, G. F. V. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5152 · Cited by 312
Self-citationPrat, M., Narsimhan, R. P., Crepaldi, T., Nicotra, M., Natali, P. G., & Comoglio, P. M. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910490302 · Cited by 287
Grimm, D., Kern, A., Pawlita, M., Ferrari, F. K., Samulski, R. J., & Kleinschmidt, J. A. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300946 · Cited by 195
Linear DNAs Concatemerize in Vivo and Result in Sustained Transgene Expression in Mouse Liver
Chen, Z.-Y., Yant, S. R., He, C.-Y., Meuse, L. A., Shen, S., & Kay, M. A. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0278 · Cited by 186
Goldman, M., & Wilson, J. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.10.5951-5958.1995 · Cited by 186
Mochizuki, H., Hayakawa, H., Migita, M., Shibata, M., Tanaka, R., Suzuki, A., Shimo-Nakanishi, Y., Urabe, T., YAMADA, M., Tamayose, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191107398 · Cited by 161
Self-citationRecombinant AAV serotype 1 transduction efficiency and tropism in the murine brain
Wang, C., Wang, C.-M., Clark, K. R., & Sferra, T. J. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302011 · Cited by 139
Expression of the C– Met Protooncogene in Human Hepatocellular Carcinoma
Suzuki, K., Hayashi, N., Yamada, Y., Yoshihara, H., Miyamoto, Y., Ito, Y., Ito, T., Katayama, K., Sasaki, Y., Ito, A., et al. (1994) · Hepatology · doi:10.1002/hep.1840200520 · Cited by 125
Guo, C., Li, Y., Tian, S., Wang, X., Douglas, S. D., & Ho, W. (2002) · Journal of Investigative Medicine · doi:10.1136/jim-50-06-03 · Cited by 119
Adeno-Associated Virus Type 2 Binds to a 150-Kilodalton Cell Membrane Glycoprotein
Mizukami, H., Young, N. S., & Brown, K. E. (1996) · Virology · doi:10.1006/viro.1996.0099 · Cited by 105
Expression of β1, β3, β4, and β5 Integrins by Human Lung Carcinoma Cells of Different Histotypes
Falcioni, R., Cimino, L., Gentileschi, M. P., D’Agnano, I., Zupi, G., Kennel, S. J., & Sacchi, A. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1017 · Cited by 84
Tumorigenicity of the met Proto-Oncogene and the Gene for Hepatocyte Growth Factor
Rong, S., Bodescot, M., Blair, D. G., Dunn, J., Nakamura, T., Mizuno, K., Park, M., Chan, A. M.-L., Aaronson, S. A., & Woude, G. F. V. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5152-5158.1992 · Cited by 83
Self-citationWendtner, C., Kofler, D. M., Theiss, H. D., Kurzeder, C., Buhmann, R., Schweighofer, C. D., Perabò, L., Danhauser-Riedl, S., Baumert, J., Hiddemann, W., et al. (2002) · Blood · doi:10.1182/blood.v100.5.1655.h81702001655_1655_1661 · Cited by 77
Lyon, M., Deakin, J. A., & Gallagher, J. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107506200 · Cited by 76
Biochemical study of KB-cell receptor for adenovirus
Hennache, B., & Boulanger, P. A. (1977) · Biochemical Journal · doi:10.1042/bj1660237 · Cited by 65
Protein Kinase C Controls Microtubule-based Traffic but Not Proteasomal Degradation of c-Met
Kermorgant, S., Zicha, D., & Parker, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302116200 · Cited by 63
Mitchell, M., Jerebtsova, M., Ml, B., Newman, K. D., & Ye, X. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301332 · Cited by 62
Cooper, C. S., Tempest, P. R., Beckman, M., Heldin, C., & Brookes, P. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04543.x · Cited by 62
Lock, L. S., Frigault, M. M., Saucier, C., & Park, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302675200 · Cited by 51
CaM I mRNA is localized to apical dendrites during postnatal development of neurons in the rat brain
Berry, F., & Brown, I. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960301)43:5 · Cited by 41
Self-citationBarani, A. E., Sabido, O., & Freyssenet, D. G. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00030-7 · Cited by 20
Guo, C., Li, Y., Tian, S., Wang, X., Douglas, S. D., & Ho, W. (2002) · Journal of Investigative Medicine · doi:10.1097/00042871-200211010-00027 · Cited by 16
Cited by
Sorted by citations
Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
Naso, M. F., Tomkowicz, B., Perry, W. L., & Strohl, W. R. (2017) · BioDrugs · doi:10.1007/s40259-017-0234-5 · Cited by 1,362
Gene therapy using adeno-associated virus vectors
Daya, S., & Berns, K. I. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-08 · Cited by 926
“Internalization is enhanced by interactions with one or more of at least six known coreceptors including V5 integrins (63), fibroblast growth factor receptor 1 (53), hepatocyte growth factor receptor ( 35 ), v1 integrin (7), and laminin receptor (3).”
BackgroundAdeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy
Wu, Z., Asokan, A., & Samulski, R. J. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.05.009 · Cited by 957
“Subsequent interactions with human fibroblast growth factor receptor 1 (FGFR1) [73], hepatocyte growth factor receptor [74], and integrins aVh5/a5h1 ([75], A.”
BackgroundZhong, L., Li, B., Mah, C. S., Govindasamy, L., Agbandje-McKenna, M., Cooper, M., Herzog, R. W., Zolotukhin, I., Warrington, K. H., Weigel-Van Aken, K. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802866105 · Cited by 558
An essential receptor for adeno-associated virus infection
Pillay, S., Meyer, N. L., Puschnik, A. S., Davulcu, O., Diep, J., Ishikawa, Y., Jae, L. T., Wosen, J. E., Nagamine, C. M., Chapman, M. S., et al. (2016) · Nature · doi:10.1038/nature16465 · Cited by 532
Metadata
- Authors
- Kashiwakura, Y., Tamayose, K., Iwabuchi, K., Hirai, Y., Shimada, T., Matsumoto, K., Nakamura, T., Watanabe, M., Oshimi, K., & Daida, H.
- Affiliations
- Juntendo University (JP)
- Nippon Medical School (JP)
- The University of Osaka (JP)
- Okayama University (JP)
- Departments of Cardiology
- Corresponding author
- Tamayose, Kenji
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-01
- Volume
- 79
- Issue
- 1
- Pages
- 609-614
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC538679
- OpenAlex
- W2120683337
- Cited by
- 246
- References
- 37
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 16 · 2020: 10 · 2019: 12 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 15 · 2014: 8 · 2013: 13 · 2012: 12
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- adeno-associated virus type 2, c-Met, co-receptors, viral entry, heparan sulfate proteoglycans, integrin αvβ5, FGFR1, transgene expression, viral internalization, receptor interaction
- MeSH terms
- Dependovirus, Animals, Cricetinae, HeLa Cells, Humans, Receptors, Virus, Transduction, Genetic, CHO Cells, 3T3 Cells, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
