The DOI matches its Crossref record.
Dengue Fever in Humanized NOD/SCID Mice
Open accessAbstract
The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans (50 to 100 million infections/year) (World Health Organization, Fact sheet 117, 2002). There are no vaccines or treatment for DF or DHF because there are no animal or other models of human disease; even higher primates do not show symptoms after infection (W. F. Scherer, P. K. Russell, L. Rosen, J. Casals, and R. W. Dickerman, Am. J. Trop. Med. Hyg. 27: 590-599, 1978). We demonstrate that nonobese diabetic/severely compromised immunodeficient (NOD/SCID) mice xenografted with human CD34 + cells develop clinical signs of DF as in humans (fever, rash, and thrombocytopenia), when infected in a manner mimicking mosquito transmission (dose and mode). These results suggest this is a valuable model with which to study pathogenesis and test antidengue products.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Agarwal, Y., Beatty, C., Ho, S., Thurlow, L., Das, A., Kelly, S., Castronova, I., Salunke, R., Biradar, S., Yeshi, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71548-z · Cited by 38
What we are learning on HTLV-1 pathogenesis from animal models
Dodon, M. D., Villaudy, J., Gazzolo, L., Haines, R., & Lairmore, M. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00320 · Cited by 23
Metadata
- Authors
- Bente, D. A., Melkus, M. W., Garcia, J. V., & Rico-Hesse, R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-11
- Volume
- 79
- Issue
- 21
- Pages
- 13797-13799
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2157908499
- Cited by
- 159
- References
- 0
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dengue Fever in Humanized NOD/SCID Mice. https://app.cochat.ai/papers/10.1128/jvi.79.21.13797-13799.2005
- The paper
- Bente, D. A., Melkus, M. W., Garcia, J. V., & Rico-Hesse, R. (2005). Dengue Fever in Humanized NOD/SCID Mice. Journal of Virology. https://doi.org/10.1128/jvi.79.21.13797-13799.2005
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
