The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization
Open accessAbstract
The recent emergence of highly pathogenic avian influenza virus (HPAI) strains in poultry and their subsequent transmission to humans in Southeast Asia have raised concerns about the potential pandemic spread of lethal disease. In this paper we describe the development and testing of an adenovirus-based influenza A virus vaccine directed against the hemagglutinin (HA) protein of the A/Vietnam/1203/2004 (H5N1) (VN/1203/04) strain isolated during the lethal human outbreak in Vietnam from 2003 to 2005. We expressed different portions of HA from a recombinant replication-incompetent adenoviral vector, achieving vaccine production within 36 days of acquiring the virus sequence. BALB/c mice were immunized with a prime-boost vaccine and exposed to a lethal intranasal dose of VN/1203/04 H5N1 virus 70 days later. Vaccination induced both HA-specific antibodies and cellular immunity likely to provide heterotypic immunity. Mice vaccinated with full-length HA were fully protected from challenge with VN/1203/04. We next evaluated the efficacy of adenovirus-based vaccination in domestic chickens, given the critical role of fowl species in the spread of HPAI worldwide. A single subcutaneous immunization completely protected chickens from an intranasal challenge 21 days later with VN/1203/04, which proved lethal to all control-vaccinated chickens within 2 days. These data indicate that the rapid production and subsequent administration of recombinant adenovirus-based vaccines to both birds and high-risk individuals in the face of an outbreak may serve to control the pandemic spread of lethal avian influenza.
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Fleeton, M. N., Chen, M., Berglund, P., Rhodes, G., Parker, S. E., Murphy, M., Atkins, G. J., & Liljeström, P. (2001) · The Journal of Infectious Diseases · doi:10.1086/319857 · Cited by 157
Cited by
Kim, E., Erdos, G., Huang, S., Kenniston, T. W., Balmert, S. C., Carey, C. D., Raj, V. S., Epperly, M. W., Klimstra, W. B., Haagmans, B. L., et al. (2020) · eBioMedicine · doi:10.1016/j.ebiom.2020.102743 · Cited by 404
Self-citationHuman infection with highly pathogenic H5N1 influenza virus
Gambotto, A., Barratt-Boyes, S. M., de Jong, M. D., Neumann, G., & Kawaoka, Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60627-3 · Cited by 316
Self-citationSandbulte, M. R., Jimenez, G. S., Boon, A. C. M., Smith, L. R., Treanor, J. J., & Webby, R. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040059 · Cited by 295
Suguitan, A. L., McAuliffe, J., Mills, K. L., Jin, H., Duke, G., Lu, B., Luke, C. J., Murphy, B., Swayne, D. E., Kemble, G., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030360 · Cited by 272
Self-citationScientific barriers to developing vaccines against avian influenza viruses
Subbarao, K., & Joseph, T. (2007) · Nature Reviews Immunology · doi:10.1038/nri2054 · Cited by 255
Metadata
- Authors
- Gao, W., Soloff, A. C., Lu, X., Montecalvo, A., Nguyen, D. C., Matsuoka, Y., Robbins, P. D., Swayne, D. E., Donis, R. O., Katz, J. M., Barratt-Boyes, S. M., & Gambotto, A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-02-15
- Volume
- 80
- Issue
- 4
- Pages
- 1959-1964
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2101954404
- Cited by
- 270
- References
- 1
- FWCI
- 23.46
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Gao, W., Soloff, A. C., Lu, X., Montecalvo, A., Nguyen, D. C., Matsuoka, Y., Robbins, P. D., Swayne, D. E., Donis, R. O., Katz, J. M., Barratt-Boyes, S. M., & Gambotto, A. (2006). Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization. Journal of Virology. https://doi.org/10.1128/jvi.80.4.1959-1964.2006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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