Separation of two types of adeno-associated virus particles containing complementary polynucleotide chains
Open accessAbstract
An adeno-associated virus containing bromodeoxyuridine-substituted deoxyribonucleic acid has been fractionated by equilibrium centrifugation in CsCl into two classes of virions which contain complementary polynucleotide chains.
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AAVs are small (icosahedral capsid of ~26 nm diameter), non-pathogenic, non-enveloped, single-stranded linear DNA-containing viruses.
“Adeno associated viruses (AAVs) are small (with an icosahederal capsid of ~26 nm diameter), non-pathogenic, non-enveloped, single-stranded linear DNA-containing viruses.”
From The Ocular Gene Delivery Landscape (2021) · cites this paper as [59]
AAVs belong to the family Parvoviridae and genus Dependovirus because they can infect only in the presence of a helper virus.
“They belong to the family Parvoviridae and genus Dependovirus because they can infect only in the presence of a helper virus [59].”
From The Ocular Gene Delivery Landscape (2021) · cites this paper as [59]
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References 7 · Cited by 101
- Authors
- Berns, K. I., & Adler, S.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1972-02
- Volume
- 9
- Issue
- 2
- Pages
- 394-396
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC356306
- OpenAlex
- W1573172871
- Cited by
- 101
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Keywords
- adeno-associated virus, viral DNA
- MeSH terms
- Adenoviridae, Bromodeoxyuridine, Carcinoma, Cell Line, Centrifugation, Density Gradient, DNA, Single-Stranded, DNA, Viral, Helper Viruses, Humans, Methods, Mouth Neoplasms, Nucleic Acid Denaturation, Nucleic Acid Renaturation, Phosphorus Isotopes, Polynucleotides, Tritium
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