Identification of the Bacterial Biosynthetic Gene Clusters of the Oral Microbiome Illuminates the Unexplored Social Language of Bacteria during Health and Disease
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Abstract
The healthy oral microbiome is symbiotic with the human host, importantly providing colonization resistance against potential pathogens. Dental caries and periodontitis are two of the world’s most common and costly chronic infectious diseases and are caused by a localized dysbiosis of the oral microbiome. Bacterially produced small molecules, often encoded by BGCs, are the primary communication media of bacterial communities and play a crucial, yet largely unknown, role in the transition from health to dysbiosis. This study provides a comprehensive mapping of the BGC repertoire of the human oral microbiome and identifies major differences in health compared to disease. Furthermore, BGC representation and expression is linked to the abundance of particular oral bacterial taxa in health versus dental caries and periodontitis. Overall, this study provides a significant insight into the chemical communication network of the healthy oral microbiome and how it devolves in the case of two prominent diseases.
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In periodontal disease, there is a characteristic shift in the composition of oral bacteria that is in part mediated by bacterial metabolites.
“In periodontal disease, there is a characteristic shift in the composition of oral bacteria that is in part mediated by bacterial metabolites.95”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [95]
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References 62 · Cited by 107
- Authors
- Aleti, G., Baker, J. L., Tang, X., Alvarez, R., Dinis, M., Tran, N. C., Melnik, A. V., Zhong, C., Ernst, M., Dorrestein, P. C., & Edlund, A.
- Affiliations
- J. Craig Venter Institute (US)
- School of Dentistry, The University of California, Los Angeles, California, USA
- University of California, Los Angeles (US)
- University of California San Diego (US)
- University of Kansas (US)
- Corresponding author
- Edlund, Anna
- ORCID
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2019-04-30
- Volume
- 10
- Issue
- 2
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC6469967
- OpenAlex
- W2951980953
- Cited by
- 107
- References
- 62
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 15 · 2023: 18 · 2022: 11 · 2021: 21 · 2020: 16 · 2019: 6
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- KU ScholarWorks (University of Kansas) (submittedVersion, cc-by)
- KU ScholarWorks (The University of Kansas) (submittedVersion, cc-by)
- Funders
- HHS | NIH | National Institute of Dental and Craniofacial Research (R00DE024543, F32DE026947)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- biosynthetic gene clusters, oral microbiota, dental caries, periodontitis, dysbiosis, bacterial secondary metabolites, host-microbe symbiosis, colonization resistance
- MeSH terms
- Bacteria, Child, Child, Preschool, Dental Caries, Multigene Family, Humans, Mouth, Periodontitis, Saliva, Mass Spectrometry, Computational Biology, Biosynthetic Pathways, Metagenome, Microbial Interactions, Microbiota, Dysbiosis
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