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Cited by 89Toxoplasma gondii Research StudiesParasitic infections in humans and animalsCoccidia and coccidiosis research

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Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

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Fox, Barbara A., Guevara, Rebekah B., Rommereim, Leah M., Falla, Alejandra, Bellini, Valeria, Pètre, Graciane, Rak, Camille, Cantillana, Viviana, Dubremetz, Jean-François, Cesbron-Delauw, Marie-France, Taylor, Gregory A., Mercier, Corinne, Bzik, David J.·2019·mBio
DOI 10.1128/mbio.00589-19PMC PMC6606796
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Abstract

Toxoplasma gondii cysts reactivate during immune deficiency and cause fatal encephalitis. Parasite molecules that coordinate the development of acute and chronic infection are poorly characterized. Here, we show that many intravacuolar network membrane and parasitophorous vacuole membrane-associated dense granule (GRA) proteins orchestrate the development of chronic cysts in vivo . A subset of these GRA proteins also modulate acute virulence, and one protein that associates with the intravacuolar network membranes, namely GRA12, was identified as a major virulence factor required for parasite resistance to host gamma interferon (IFN-γ). Our results revealed that many parasitophorous vacuole membrane and intravacuolar network membrane-associated GRA proteins are essential for successful chronic infection.

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Research works printed but not linked: 111

  1. 10.1016/S0020-7519(00)00124-7 · DOI
  2. 10.1016/B978-012369542-0/50003-9 · DOI
  3. 10.1086/590149 · DOI
  4. 10.1146/annurev-micro-091014-104353 · DOI
  5. 10.1146/annurev.micro.62.081307.162925 · DOI
  6. 10.1038/nmicrobiol.2016.1 · DOI · Paper page
  7. 10.1111/j.1462-5822.2011.01681.x · DOI
  8. 10.1371/journal.ppat.1003823 · DOI
  9. 10.2741/A521 · DOI
  10. 10.1371/journal.ppat.1005447 · DOI
  11. 10.4303/jnp/N100505 · DOI
  12. 10.1093/clinids/15.2.211 · DOI
  13. 10.1016/j.ijpara.2009.02.004 · DOI
  14. 10.1126/science.1094717 · DOI
  15. Carruthers VB, Sibley LD. 1997. Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts. Eur J Cell Biol 73:114–123.
  16. 10.1016/j.pt.2014.12.002 · DOI
  17. 10.1017/S0031182005007559 · DOI
  18. 10.1128/IAI.01667-07 · DOI
  19. 10.1073/pnas.1313501111 · DOI
  20. 10.1111/cmi.12499 · DOI
  21. 10.1371/journal.ppat.1002992 · DOI
  22. 10.1371/journal.pgen.1005434 · DOI
  23. 10.1073/pnas.1015338108 · DOI
  24. 10.1016/j.chom.2014.04.002 · DOI
  25. 10.1016/j.chom.2010.11.005 · DOI
  26. 10.1371/journal.pbio.1001358 · DOI
  27. 10.1128/mBio.00193-16 · DOI
  28. 10.1371/journal.ppat.1002784 · DOI
  29. 10.1074/jbc.M114.567057 · DOI
  30. 10.1073/pnas.1015980108 · DOI
  31. 10.1126/science.1133690 · DOI
  32. 10.1016/j.ijpara.2015.10.005 · DOI
  33. 10.1126/science.1133643 · DOI
  34. 10.1038/s41598-017-05487-7 · DOI
  35. 10.1073/pnas.1515966112 · DOI
  36. 10.1128/IAI.00734-15 · DOI
  37. 10.1016/j.cell.2006.01.056 · DOI
  38. 10.1371/journal.pone.0159306 · DOI
  39. 10.1007/s00436-019-06298-7 · DOI
  40. 10.1128/IAI.00782-08 · DOI
  41. 10.1128/IAI.01185-12 · DOI
  42. 10.1016/j.chom.2011.04.015 · DOI
  43. 10.1084/jem.20100717 · DOI
  44. 10.1016/j.jsb.2015.05.003 · DOI
  45. 10.1242/jcs.108.4.1669 · DOI
  46. 10.7554/eLife.24119 · DOI
  47. 10.1016/0014-4894(90)90014-4 · DOI
  48. 10.1242/jcs.111.15.2171 · DOI
  49. 10.1016/S0166-6851(99)00092-4 · DOI
  50. 10.1016/0166-6851(95)00010-X · DOI
  51. 10.1016/j.ijpara.2004.07.011 · DOI
  52. 10.1016/j.ijpara.2008.07.011 · DOI
  53. 10.1016/j.celrep.2015.11.001 · DOI
  54. 10.1091/mbc.e02-01-0021 · DOI
  55. 10.1016/j.ijpara.2007.10.010 · DOI
  56. 10.1084/jem.20131272 · DOI
  57. 10.1128/IAI.66.9.4176-4182.1998 · DOI
  58. 10.1158/0008-5472.CAN-12-1974 · DOI
  59. 10.1371/journal.pgen.1006189 · DOI
  60. 10.1091/mbc.E12-11-0827 · DOI
  61. 10.1128/EC.00002-11 · DOI
  62. 10.1371/journal.ppat.1006362 · DOI
  63. 10.1083/jcb.201701108 · DOI
  64. 10.1128/mBio.01188-14 · DOI
  65. 10.1038/nmicrobiol.2017.96 · DOI
  66. 10.1128/EC.00297-10 · DOI
  67. 10.1016/j.ijpara.2003.11.024 · DOI
  68. 10.1128/mBio.00469-19 · DOI
  69. 10.1038/s41598-018-36671-y · DOI
  70. 10.1098/rstb.1997.0119 · DOI
  71. 10.1371/journal.ppat.1005211 · DOI
  72. 10.1128/EC.00357-08 · DOI
  73. 10.1111/j.1462-5822.2010.01443.x · DOI
  74. 10.1189/jlb.1008599 · DOI
  75. 10.1186/s12915-016-0255-4 · DOI
  76. 10.1016/j.micinf.2017.12.003 · DOI
  77. 10.1007/BF00931588 · DOI
  78. 10.1128/iai.62.5.1761-1767.1994 · DOI
  79. 10.1016/S0169-4758(99)01515-X · DOI
  80. 10.1371/journal.ppat.1003331 · DOI
  81. 10.1128/mBio.02048-16 · DOI
  82. 10.1016/j.molbiopara.2007.02.013 · DOI
  83. 10.7554/eLife.10809 · DOI
  84. 10.1128/IAI.73.6.3278-3286.2005 · DOI
  85. 10.1128/mSphere.00045-16 · DOI
  86. 10.3389/fcell.2018.00118 · DOI
  87. 10.1016/j.coi.2018.06.008 · DOI
  88. 10.1074/jbc.M111.251967 · DOI
  89. 10.1371/journal.ppat.1003414 · DOI
  90. 10.1128/mBio.00808-16 · DOI
  91. 10.1016/j.chom.2015.04.003 · DOI
  92. 10.1128/mBio.02231-15 · DOI
  93. 10.1371/journal.ppat.1006828 · DOI
  94. 10.1128/mBio.02401-17 · DOI
  95. 10.1128/IAI.00287-10 · DOI
  96. 10.1016/j.ijpara.2003.12.001 · DOI
  97. 10.4049/jimmunol.182.2.1069 · DOI
  98. 10.4049/jimmunol.172.5.3003 · DOI
  99. 10.1371/journal.pone.0060215 · DOI
  100. 10.3791/50598:e50598 · DOI
  101. 10.1038/415926a · DOI
  102. 10.1002/cyto.a.21138 · DOI
  103. 10.1093/nar/gkm981 · DOI
  104. 10.1017/S0031182000059837 · DOI
  105. 10.1089/hyb.1990.9.453 · DOI
  106. 10.1016/S0166-6851(99)00160-7 · DOI
  107. 10.1016/S0092-8674(00)81071-5 · DOI
  108. 10.1002/eji.1830150721 · DOI
  109. 10.1038/nmeth.2019 · DOI · Paper page
  110. 10.3791/2091 · DOI
  111. 10.17226/12910 · DOI · Paper page

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Metadata

Authors
Fox, B. A., Guevara, R. B., Rommereim, L. M., Falla, A., Bellini, V., Pètre, G., Rak, C., Cantillana, V., Dubremetz, J.-F., Cesbron-Delauw, M.-F., Taylor, G. A., Mercier, C., & Bzik, D. J.
Affiliations
  • Dartmouth College (US)
  • Laboratoire Techniques de l’Ingénierie Médicale et de la Complexité—Informatique, Mathématiques, Applications, Grenoble (TIMC-IMAG), Université Grenoble Alpes, Grenoble, France
  • Centre National de la Recherche Scientifique (FR)
  • Duke Medical Center (US)
Corresponding author
Bzik, David J.
ORCID
Venue
mBio
Publisher
American Society for Microbiology
Published
2019-08-27
Volume
10
Issue
4
ISSN
  • 2150-7511 (ISSN-L)
  • 2161-2129
DOI
10.1128/mbio.00589-19
PMC
PMC6606796
OpenAlex
W2955044791
Cited by
89
References
0
Citations by year
2026: 6 · 2025: 8 · 2024: 15 · 2023: 14 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 6
FWCI
8.87
Type
journal article
Language
en
Open access
Licence
Locations
  • mBio (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Veterans Health Administration (BX002369)
  • HHS | National Institutes of Health (AI041930, AI075931, AI084570, AI104514, AI105563, AI108489, AI129869, AI131630, AI137118, 5T32AI007363, 2T32AI007519, AI135398)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Toxoplasma gondii Research Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Coccidia and coccidiosis research
Keywords
Toxoplasma gondii, dense granule proteins, parasitophorous vacuole membrane, chronic infection, host-parasite interactions, encephalitis
MeSH terms
Animals, Cell Survival, Cells, Cultured, Disease Models, Animal, Female, Interferon-gamma, Intracellular Membranes, Mice, Inbred C57BL, Models, Theoretical, Toxoplasma, Toxoplasmosis, Vacuoles, Virulence, Protozoan Proteins, Survival Analysis, Gene Deletion, Mice, Knockout, Virulence Factors, Host-Pathogen Interactions, Immune Evasion

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