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S51 Family Peptidases Provide Resistance to Peptidyl-Nucleotide Antibiotic McC
Open accessPublished version of a preprint
Abstract
Here, we identified a natural substrate for a major phylogenetic clade of poorly characterized S51 family proteases from bacteria. We show that these proteins can contribute to a basal level of resistance to an important class of natural antibiotics.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Metadata
- Authors
- Yagmurov, E., Gilep, K., Serebryakova, M., Wolf, Y. I., Dubiley, S., & Severinov, K.
- Affiliations
- Skolkovo Institute of Science and Technology (RU)
- Russian Academy of Sciences (RU)
- National Institutes of Health (US)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Dubiley, Svetlana
- Severinov, Konstantin
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2022-06-28
- Volume
- 13
- Issue
- 3
- Pages
- e0080522-e0080522
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC9239234
- OpenAlex
- W4224443949
- Cited by
- 1
- References
- 1
- Citations by year
- 2025: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Russian Science Foundation (19-14-00266)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- antibiotic resistance, bacterial proteases, phylogenetic clades, natural products
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Bacteriocins, Nucleotides, Peptide Hydrolases, Peptides, Phylogeny
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