Genomic Diversity of Azole-Resistant Aspergillus fumigatus in the United States
Open accessAbstract
Aspergillus fumigatus is one of the most common causes of invasive mold infections in patients with immune deficiencies and has also been reported in patients with severe influenza and severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2). Triazole drugs are the first line of therapy for this infection; however, their efficacy has been compromised by the emergence of azole resistance in A. fumigatus , which was proposed to be selected for by exposure to azole fungicides in the environment [P.
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Recent genomic analysis of A. fumigatus isolates from the United States suggests a single introduction of a strain with the TR34/L98H substitution resulted in widespread distribution throughout susceptible Aspergillus populations through recombination.
“Recent genomic analysis of A. fumigatus isolates from the United States suggests a single introduction of a strain with the TR34/L98H substitution resulted in widespread distribution throughout susceptible Aspergillus populations through recombination between resistant and susceptible isolates23.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [23]
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References 54 · Cited by 48
Research works printed but not linked: 2
- [34]Kang SE, Sumabat LG, Melie T, Mangum B, Momany M, Brewer MT. 25 May 2020. Evidence for the agricultural origin of antimicrobial resistance in a fungal pathogen of humans. bioRxiv doi: 10.1101/2020.05.24.113787. PMC9210323 34897421 · DOI
- [49]Andrews S. 2010. FastQC: a quality control tool for high throughput sequence data. Babraham Bioinformatics, Babraham Institute, Cambridge, United Kingdom.
- Authors
- Etienne, K. A., Berkow, E. L., Gade, L., Nunnally, N., Lockhart, S. R., Beer, K., Jordan, I. K., Rishishwar, L., & Litvintseva, A. P.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Georgia Institute of Technology (US)
- Corresponding author
- Litvintseva, Anastasia P.
- ORCID
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2021-08-31
- Volume
- 12
- Issue
- 4
- Pages
- e0180321-e0180321
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC8406307
- OpenAlex
- W3189890289
- Cited by
- 48
- References
- 54
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 1 · 2021: 4
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- IHRC-Georgia Tech Applied Biotechnology Laboratory
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Aspergillus fumigatus, azole resistance, triazole resistance, genomic diversity, invasive aspergillosis, antifungal resistance, azole fungicides, environmental exposure, immunodeficiency, influenza, COVID-19 pandemic
- MeSH terms
- Whole Genome Sequencing, Antifungal Agents, Aspergillosis, Aspergillus fumigatus, Cytochrome P-450 Enzyme System, Fungal Proteins, Humans, Microbial Sensitivity Tests, Triazoles, United States, Genome, Fungal, Polymorphism, Single Nucleotide, Drug Resistance, Fungal
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