A Retrotranslocation Assay That Predicts Defective VCP/p97-Mediated Trafficking of a Retroviral Signal Peptide
Open accessPublished version of a preprint
Abstract
Endoplasmic reticulum-associated degradation (ERAD) is a form of cellular protein quality control that is manipulated by viruses, including the betaretrovirus, mouse mammary tumor virus (MMTV). MMTV-encoded signal peptide (SP) has been shown to interact with an essential ERAD factor, VCP/p97 ATPase, to mediate its extraction from the ER membrane, also known as retrotranslocation, for RNA binding and nuclear function.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
Mouse mammary tumor virus encodes a self-regulatory RNA export protein and is a complex retrovirus
Mertz, J. A., Simper, M. S., Lozano, M. M., Payne, S. M., & Dudley, J. P. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14737-14747.2005 · Cited by 130 · see citing works
Self-citationIdentification of the Rem-responsive element of mouse mammary tumor virus
Mullner, M., Salmons, B., Gunzburg, W. H., & Indik, S. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn608 · Cited by 34 · see citing works
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- Authors
- Das, P., Xu, W. K., Gautam, A. K. S., Lozano, M. M., & Dudley, J. P.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Dudley, Jaquelin P.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2022-02-22
- Volume
- 13
- Issue
- 1
- Pages
- e0295321-e0295321
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC8725593
- OpenAlex
- W4220906380
- Cited by
- 5
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- HHS | National Institutes of Health (CA167053, AI131660)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- retrotranslocation, ER-associated degradation, mouse mammary tumor virus, nuclear trafficking, protein quality control
- MeSH terms
- Valosin Containing Protein, Amino Acids, Animals, Cell Nucleus, Humans, Mammary Tumor Virus, Mouse, Cell Cycle Proteins, Protein Sorting Signals, Mice, Endoplasmic Reticulum-Associated Degradation
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