Pseudomonas aeruginosa FpvB Is a High-Affinity Transporter for Xenosiderophores Ferrichrome and Ferrioxamine B
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Abstract
Gram-negative bacteria express a variety of outer membrane transporters to import critical nutrients such as iron. Due to its insolubility, iron is taken up while bound to small-molecule chelators called siderophores. Pseudomonas aeruginosa takes up its own siderophores pyoverdine and pyochelin but can also steal siderophores produced by other bacteria and fungi, giving it a competitive advantage in iron-limited environments.
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Cites
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ColabFold - Making protein folding accessible to all
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- Authors
- Chan, D. C. K., & Burrows, L. L.
- Affiliations
- Michael G. DeGroote Institute for Infectious Disease Research (CA)
- Corresponding author
- Burrows, Lori L.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2023-02-28
- Volume
- 14
- Issue
- 1
- Pages
- e0314922-e0314922
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC9973354
- OpenAlex
- W4311176845
- Cited by
- 50
- References
- 6
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 17 · 2023: 6 · 2022: 2
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Canada Graduate Scholarships-D
- Canada Research Chairs (Microbe-Surface Interactions)
- Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (RGPIN-2021-04237)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Pseudomonas aeruginosa, ferrichrome, ferrioxamine B, siderophore transport, outer membrane transporters, siderophore-antibiotic conjugates, substrate specificity, iron acquisition, pyoverdine, pyochelin, site-directed mutagenesis
- MeSH terms
- Anti-Bacterial Agents, Bacterial Outer Membrane Proteins, Bacterial Proteins, Deferoxamine, Ferric Compounds, Ferrichrome, Iron, Ligands, Phenols, Pseudomonas aeruginosa, Thiazoles, Thiostrepton, Siderophores, Membrane Transport Proteins
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