CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

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Items 101–200 of 256

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2. CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G
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3. Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases
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4. Mitotic Dysfunction Associated with Aging Hallmarks
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5. Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats
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6. Mitochondrial Dysfunction, Proteotoxicity, and Aging
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7. Emerging evidence of coding mutations in the ubiquitin–proteasome system associated with cerebellar ataxias
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8. Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP
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9. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
   Chang-he Shi, Carrie E. Rubel, Sarah E. Soss, Rebekah Sanchez‐Hodge, Shuo Zhang, Sabrina C. Madrigal, Saranya Ravi, Holly McDonough, Richard C. Page, Walter Chazin et al. · 2018 · PLoS Genetics
10. Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycation.
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11. Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging
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12. The Interplay between Autophagy and Aging
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13. Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance.
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14. UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells
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16. Proteostasis and ageing: insights from long‐lived mutant mice
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17. Ancient origin of animal U-box ubiquitin ligases
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18. Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia
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19. CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling
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21. Accelerated lung aging and chronic obstructive pulmonary disease
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22. CHIP-dependent p53 regulation occurs specifically during cellular senescence
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23. Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice
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24. Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover
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26. Carboxyl Terminus of Hsp70‐Interacting Protein Regulation of Osteoclast Formation in Mice Through Promotion of Tumor Necrosis Factor Receptor–Associated Factor 6 Protein Degradation
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27. Conserved and Unique Roles of Chaperone-Dependent E3 Ubiquitin Ligase CHIP in Plants
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28. A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
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29. Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein (CHIP) Produces Specific Behavioral Impairments
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30. CHIP regulates bone mass by targeting multiple TRAF family members in bone marrow stromal cells
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31. C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside
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32. Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition
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33. Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome
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34. CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer
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35. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis
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36. How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging
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37. Multifaceted C-terminus of HSP70-interacting protein regulates tumorigenesis via protein quality control
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38. Changes in protein function underlie the disease spectrum in patients with CHIP mutations
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39. UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review
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40. A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis
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41. CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system
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42. BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway
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43. Seek and destroy: The ubiquitin-proteasome system in cardiac disease
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44. Physiological and biochemical effects of 17β estradiol in aging female rat brain
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45. Mesenchymal Stem Cell Transplantation for the Treatment of Age-Related Musculoskeletal Frailty
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46. BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72
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47. Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
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48. Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1
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49. Heat shock proteins: keys to healthy ageing?
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50. Principles of brain aging: Status and challenges of modeling human molecular changes in mice
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51. CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins
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52. Movement Disorders Associated with Hypogonadism
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53. Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration
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54. A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging
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55. A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity
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56. Regulation of the calpain and ubiquitin‐proteasome systems in a canine model of muscular dystrophy
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57. Overexpression of IGF‐IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats
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58. Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues
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60. PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
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61. Chaperone Proteins: The Rising Players in Muscle Atrophy
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62. Induction of cell proliferation, clonogenicity and cell accumulation in S phase as a consequence of human UBE2Q1 overexpression
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64. Cellular senescence and tumor promotion: Role of the Unfolded Protein Response.
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65. Stress Responses During Ageing: Molecular Pathways Regulating Protein Homeostasis
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66. STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells
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67. Ub and Down: Ubiquitin Exercise for the Elderly
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68. Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds
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69. Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress
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75. CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity
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80. Drosophila p38 MAPK interacts with BAG‐3/starvin to regulate age‐dependent protein homeostasis
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84. Plausible Links Between Metabolic Networks, Stem Cells, and Longevity
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85. Proteome solubility is differentially reshaped by thermal stress and regulators of ubiquitination
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86. Selective autophagy in kidney health and disease
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87. Breast cancer quality control
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88. CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses
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