A Novel Nuclear Signaling Pathway for Thromboxane A 2 Receptors in Oligodendrocytes: Evidence for Signaling Compartmentalization during Differentiation

The present study investigated G protein expression, localization, and functional coupling to thromboxane A(2) receptors (TPRs) during oligodendrocyte (OLG) development. It was found that as OLGs mature, the expression levels of G(q) increase while those of G(13) decrease. In contrast, the expres…