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Cited by 26

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Stimulation of Polo-Like Kinase 3 mRNA Decay by Tristetraprolin

Horner, Thierry J., Lai, Wi S., Stumpo, Deborah J., Blackshear, Perry J.·2009·Molecular and Cellular Biology
DOI 10.1128/mcb.00982-08
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  • PLK3 and VEGFA mRNAs are targets of ZFP36L1.

    “PLK3 and VEGFA mRNAs have recently been identified as targets of ZFP36L1 (7,8), whereas cMYC mRNA does not bind to ZFP36L1 or ZFP36L2.”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [7]

    The Discussion (page unavailable) identifies PLK3 mRNA as a physiological target of TTP (ZFP36), apparently specific to that family member in the tested fibroblasts. The Results report that PLK3 mRNA decay was not slowed by ZFP36L1 deficiency, contrary to the attributed PLK3 claim. The retrieved passages do not address VEGFA as a ZFP36L1 target. (LLM, conf=0.90)

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  • ZFP36 family members interact with AREs containing a UAUUUAUU sequence and trigger degradation of several ARE-containing mRNAs, including PLK3 and VEGFA.

    “ZFP36L1 and ZFP36L2 belong to the family of CCCH tandem zinc finger proteins (the ZFP36 family), members of which interact with AREs containing a UAUUUAUU sequence and trigger the degradation of several ARE-containing mRNAs, including PLK3 and VEGFA (7,8,18,19).”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [7]

    The Abstract says ZFP36 family members bind an ARE consensus site, UUAUUUAUU, which contains the claimed UAUUUAUU sequence. The Abstract and Discussion establish that TTP promotes PLK3 mRNA decay, but the Results find no equivalent effect for ZFP36L1 or ZFP36L2 in the fibroblasts studied. No passage located in our copy supports VEGFA as a target. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Endogenous ZFP36L1 interacts with PLK3 and VEGFA mRNAs.

    “We found that endogenous ZFP36L1 interacts with LDLR mRNA, and also with PLK3 and VEGFA mRNAs, previously identified ZFP36L1-interacting mRNAs (7,8).”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [7]

  • ZFP36 family proteins bind to AREs and trigger degradation of several ARE-containing mRNAs, including PLK3 and VEGFA.

    “ZFP36 family proteins bind to AREs and trigger the degradation of several ARE-containing mRNAs, including PLK3 and vascular endothelial growth factor A (VEGFA) (7,8).”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [7]

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Research works printed but not linked: 54

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Metadata

Authors
Horner, T. J., Lai, W. S., Stumpo, D. J., & Blackshear, P. J.
Affiliations
Laboratory of Signal Transduction
Venue
Molecular and Cellular Biology
Publisher
Informa UK Limited
Published
2009-04
Volume
29
Issue
8
Pages
1999-2010
ISSN
1098-5549
DOI
10.1128/mcb.00982-08
Cited by
26
References
0
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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