The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen.
Open accessAbstract
The rol-6 gene is one of the more than 40 loci in Caenorhabditis elegans that primarily affect organismal morphology. Certain mutations in the rol-6 gene produce animals that have the right roller phenotype, i.e., they are twisted into a right-handed helix. The rol-6 gene interacts with another gene that affects morphology, sqt-1; a left roller allele of sqt-1 acts as a dominant suppressor of a right roller allele of rol-6. The sqt-1 gene has previously been shown to encode a collagen. We isolated and sequenced the rol-6 gene and found that it also encodes a collagen. The rol-6 gene was identified by physical mapping of overlapping chromosomal deficiencies that cover the gene and by identification of an allele-specific restriction site alteration. The amino acid sequence of the collagen encoded by rol-6 is more similar to that of the sqt-1 collagen than to any of the other ten C. elegans cuticle collagen sequences compared. The locations of cysteine residues flanking the Gly-X-Y repeat regions of rol-6 and sqt-1 are identical, but differ from those in the other collagens. The sequence similarities between rol-6 and sqt-1 indicate that they represent a new collagen subfamily in C. elegans. These findings suggest that these two collagens physically interact, possibly explaining the genetic interaction seen between the rol-6 and sqt-1 genes.
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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
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Transformation and microinjection
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Metadata
- Authors
- Kramer, J. M., French, R. P., Park, E. C., & Johnson, J. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1990-05
- Volume
- 10
- Issue
- 5
- Pages
- 2081-2089
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2171288353
- Cited by
- 331
- References
- 28
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen. https://app.cochat.ai/papers/10.1128/mcb.10.5.2081
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- Kramer, J. M., French, R. P., Park, E. C., & Johnson, J. J. (1990). The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.10.5.2081
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