The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.
Open accessAbstract
Retinoic acid is known to have profound effects on developmental processes. It has been implicated as a putative morphogen in the developing chick limb bud and regenerating amphibian limb blastema and has been demonstrated to have powerful teratogenic effects in mammals, including humans. Recently, three specific retinoic acid receptors (RARs), RAR alpha, -beta, and -gamma, were identified and shown to be members of the steroid receptor superfamily. We report the identification of a novel RAR gamma isoform, mRAR gamma B, which differs from the previously described mouse RAR gamma at its amino terminus. In addition, we show that both RAR gamma isoforms are expressed maximally at midgestation in structures known to be affected adversely by retinoic acid administration to pregnant mice. Multiple RAR isoforms, each of which may play a unique or combinatorial role as a regulator of mammalian development, are thus expressed in the mouse embryo.
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A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942
Cited by
Smith, M. A., Parkinson, D. R., Cheson, B. D., & Friedman, M. A. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.5.839 · Cited by 486
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
Zelent, A., Mendelsohn, C., Kastner, P., Krust, A., Garnier, J. M., Ruffenach, F., Leroy, P., & Chambon, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07922.x · Cited by 379
The steroid receptor superfamily: mechanisms of diversity
Fuller, P. J. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.15.1743440 · Cited by 200
Signaling pathways in retinoid chemoprevention and treatment of cancer
Niles, R. M. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.05.020 · Cited by 141
Metadata
- Authors
- Giguère, V, Shago, M., Zirngibl, R., Tate, P., Rossant, J., & Varmuza, S.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1990-05
- Volume
- 10
- Issue
- 5
- Pages
- 2335-2340
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2289456403
- Cited by
- 160
- References
- 3
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Giguère, V, Shago, M., Zirngibl, R., Tate, P., Rossant, J., & Varmuza, S. (1990). Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.10.5.2335
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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