Cited by 175Estrogen and related hormone effectsBreast Cancer Treatment StudiesCancer-related Molecular Pathways

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.

Open access

Musgrove, E A, Lee, C S, Sutherland, R L·1991·Molecular and Cellular Biology

Open this paper in CoChat — free account

Abstract

This study documents a biphasic change in the rate of cell cycle progression and proliferation of T-47D human breast cancer cells treated with synthetic progestins, consisting of an initial transient acceleration in transit through G1, followed by cell cycle arrest and growth inhibition. Both components of the response were mediated via the progesterone receptor. The data are consistent with a model in which the action of progestins is to accelerate cells already progressing through G1, which are then arrested early in G1 after completing a round of replication, as are cells initially in other phases of the cell cycle. Such acceleration implies that progestins act on genes or gene products which are rate limiting for cell cycle progression. Increased production of epidermal growth factor and transforming growth factor alpha, putative autocrine growth factors in breast cancer cells, does not appear to account for the initial response to progestins, since although the mRNA abundance for these growth factors is rapidly induced by progestins, cells treated with epidermal growth factor or transforming growth factor alpha did not enter S phase until 5 to 6 h later than those stimulated by progestin. The proto-oncogenes c-fos and c-myc were rapidly but transiently induced by progestin treatment, paralleling the well-known response of these genes to mitogenic signals in other cell types. The progestin antagonist RU 486 inhibited progestin regulation of both cell cycle progression and c-myc expression, suggesting that this proto-oncogene may participate in growth modulation by progestins.

Integrity signals

Registry

Crossref · 10.1128/mcb.11.10.5032

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The publisher hasn’t deposited this paper’s reference list.

Sorted by citations

Items 101–175 of 175

Exogenous progestagens and the human breast
Sitruk-Ware, R. L., & Plu‐Bureau, G. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.06.007 · Cited by 26
Modifications to glucocorticoid and progesterone receptors alter cell fate in breast cancer
Leehy, K. A., Anderson, T. M. R., Daniel, A. R., Lange, C. A., & Ostrander, J. H. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0322 · Cited by 25
Targeting Progesterone Receptors in Breast Cancer
Giulianelli, S., Molinolo, A., & Lanari, C. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-416673-8.00009-5 · Cited by 24
Steroidal hormones and proliferation, differentiation and apoptosis in breast cells
Gompel, A., Chaouat, M., Hugol, D., et al. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.06.009 · Cited by 24
Progesterone-Growth Factor Interactions in Uterine Stromal Cells1
Rider, V., Kimler, B. F., & Justice, W. M. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.3.464 · Cited by 24
PKCα and PKCδ Activation Regulates Transcriptional Activity and Degradation of Progesterone Receptor in Human Astrocytoma Cells
González‐Arenas, A., Peña-Ortiz, M. Á., Hansberg-Pastor, V., Marquina-Sánchez, B., Baranda-Ávila, N., Castro, K. E. N., Cabrera‐Wrooman, A., González-Jorge, J., & Camacho‐Arroyo, I. (2014) · Endocrinology · doi:10.1210/en.2014-1137 · Cited by 23
Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities
Labrie, F., Labrie, C., BÉLANGER, A., Giguère, V., Simard, J., Mérand, Y., Gauthier, S., Luu-The, V., Candas, B., Martel, C., et al. (2001) · Advances in protein chemistry · doi:10.1016/s0065-3233(01)56009-x · Cited by 22
Do Progestogens Reduce The Risk of Breast Cancer? A Review of the Evidence
Wren, B. G., & Eden, J. (1996) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-199603010-00003 · Cited by 23
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines
Schoonen, W. G. E. J., Joosten, J. W. H., & Kloosterboer, H. J. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00216-2 · Cited by 23
Epidermal growth factor receptor signaling pathway involved in progestin‐resistance of human endometrial carcinoma: In a mouse model
Xu, Y., Tong, J., Ai, Z., et al. (2012) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2012.01881.x · Cited by 22
The interplay between intracellular progesterone receptor and PKC plays a key role in migration and invasion of human glioblastoma cells
Marquina-Sánchez, B., González-Jorge, J., Hansberg-Pastor, V., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.10.001 · Cited by 22
Epidermal growth factor suppresses induction by progestin of the adhesion protein desmoplakin in T47D breast cancer cells
Pang, H., Rowan, B. G., Al-Dhaheri, M. H., et al. (2004) · Breast Cancer Research · doi:10.1186/bcr780 · Cited by 22
Overlapping but Distinct Profiles of Gene Expression Elicited by Glucocorticoids and Progestins
Wan, Y. (2003) · Recent Progress in Hormone Research · doi:10.1210/rp.58.1.199 · Cited by 22
Hormone replacement therapy after breast cancer: a review
Eden, J., & Wren, B. G. (1996) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(96)90006-7 · Cited by 22
Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells
Gupta, A., Mehta, R. R., Mehta, R. R., et al. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.08.004 · Cited by 21
Cyclins and breast cancer
Sweeney, K. J. E., Musgrove, E. A., Watts, C. K. W., & Sutherland, R. L. (1996) · Cancer treatment and research · doi:10.1007/978-1-4613-1259-8_8 · Cited by 21
Self-citation
The origin of breast cancer
Wren, B. G. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31803816db · Cited by 20
Control of Endothelin-A Receptor Expression by Progesterone Is Enhanced by Synergy With Gata2
Zhang, Y., Knutsen, G. R., Brown, M. D., & Ruest, L. B. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1334 · Cited by 20
The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5
Hilton, H. N., Kalyuga, M., Cowley, M. J., Alles, M. C., Lee, H. J., Caldon, C. E., Blazek, K. D., Kaplan, W. H., Musgrove, E. A., Daly, R. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0516 · Cited by 19
Self-citation
Percutaneous Progesterone Use and Risk of Breast Cancer: Results from a French Cohort Study of Premenopausal Women with Benign Breast Disease
Plu-Bureau, Lê, Thalabard, et al. (1999) · Cancer Detection and Prevention · doi:10.1046/j.1525-1500.1999.99032.x · Cited by 19
Identification of therapeutic targets for breast cancer using biological informatics methods
LIU, X., Ma, Y., Yang, W., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3565 · Cited by 18
C-myc as a predictive marker for chemotherapy in metastatic breast cancer
Todorović‐Raković, N., Nešković‐Konstantinović, Z., & Nikolić‐Vukosavljević, D. (2011) · Clinical and Experimental Medicine · doi:10.1007/s10238-011-0169-y · Cited by 18
HDLG5/KIAA0583, encoding a MAGUK‐family protein, is a primary progesterone target gene in breast cancer cells
Purmonen, S., Ahola, T. M., Pennanen, P. T., Aksenov, N., Zhuang, Y., Tuohimaa, P., & Ylikomi, T. J. (2002) · International Journal of Cancer · doi:10.1002/ijc.10665 · Cited by 18
Transit of Normal Rat Uterine Stromal Cells through G1 Phase of the Cell Cycle Requires Progesterone-Growth Factor Interactions
Jones, S. R., Kimler, B. F., Justice, W. M., et al. (2000) · Endocrinology · doi:10.1210/endo.141.2.7332 · Cited by 18
A Mathematical Model of Cell Cycle Progression Applied to the MCF-7 Breast Cancer Cell Line
Simms, K. T., Bean, N. G., & Koerber, A. J. (2011) · Bulletin of Mathematical Biology · doi:10.1007/s11538-011-9700-2 · Cited by 16
Progestins regulate genes that can elicit both proliferative and antiproliferative effects in breast cancer cells
Pennanen, P. T., Ylikomi, T. J., Manninen, T., & Purmonen, S. (2008) · Oncology Reports · doi:10.3892/or.19.6.1627 · Cited by 15
Prolonged progestin treatment induces the promoter of CDK inhibitor p21Cip1,Waf1 through activation of p53 in human breast and endometrial tumor cells
Kester, H. A., Sonneveld, E., van der Saag, P. T., & van der Burg, B. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00017-4 · Cited by 15
Postmenopausal estrogen–progestin therapy and breast cancer: a clinical response to epidemiological reports
Speroff, L. (2000) · Climacteric · doi:10.3109/13697130009167593 · Cited by 14
Integrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone
Wei, M., He, Q., Yang, Z., Wang, Z., Zhang, Q., Liu, B., Gu, Q., Su, L., Yu, Y., Zhu, Z., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-10 · Cited by 13
High Levels of Progesterone Receptor B in MCF-7 Cells Enable Radical Anti-Tumoral and Anti-Estrogenic Effect of Progestin
Bajalović, N., Or, Y. Z., Woo, A. R. E., Lee, S. H., & Lin, V. C. L. (2022) · Biomedicines · doi:10.3390/biomedicines10081860 · Cited by 13
Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
Desreux, J., Kebers, F., Noël, A., et al. (2003) · The Breast · doi:10.1016/s0960-9776(03)00003-1 · Cited by 13
Steroidal Regulation of Cell Cycle Progression
Sutherland, R. L., Hamilton, J. A., Sweeney, K. J. E., et al. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514757.ch13 · Cited by 12
Self-citation
Progestins in the menopause in healthy women and breast cancer patients
Pasqualini, J. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2008.12.008 · Cited by 11
BRCA1 Attenuates Progesterone Effects on Proliferation and NFκB Activation in Normal Human Mammary Epithelial Cells
Hilton, H. N., McDonald, L. J. P., Santucci, N., van der Bent, F. R., Silvestri, A., Graham, J. D., & Clarke, C. L. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09431-5 · Cited by 11
6 The breast and the menopause
Wren, B. G. (1996) · Baillière s Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(96)80024-1 · Cited by 9
Effects of different progestogens on human breast tumor cell growth
Chen, F.-P., Chien, M., Chen, H.-Y., & Ng, Y. T. (2011) · Climacteric · doi:10.3109/13697137.2010.548565 · Cited by 8
Dydrogesterone and other progestins in benign breast disease: an overview
Schindler, A. E. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1456-7 · Cited by 8
Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue
Evers, N. M., van de Klundert, T. M. C., van Aesch, Y. M., Wang, S., de Roos, W. K., Romano, A., de Haan, L. H. J., Murk, A. J., EDERVEEN, A. G. H., Rietjens, I. M. C. M., et al. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.04.014 · Cited by 7
Metabolism of megestrol acetate in vitro and the role of oxidative metabolites
House, L. K., Seminerio, M. J., Mirkov, S., Ramı́rez, J., Skor, M. N., Sachleben, J. R., Isikbay, M., Singhal, H., Greene, G. L., Griend, D. J. V., et al. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1386335 · Cited by 7
Increased levels of the cell cycle inhibitor protein, dacapo, accompany 20‐hydroxyecdysone‐induced G1 arrest in a mosquito cell line
Gerenday, A., & Fallon, A. M. (2011) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20440 · Cited by 7
The Selective Estrogen Enzyme Modulators (SEEM) in Breast Cancer
Chetrite, G. S. (2002) · CRC Press eBooks · doi:10.1201/b14039-8 · Cited by 7
Chemoprevention of Breast Cancer
Fabian, C., & Kimler, B. (2002) · Drugs & Aging · doi:10.2165/00002512-200219010-00004 · Cited by 8
Role of Progestins and Progesterone Receptors in Breast Cancer Biology
Guiochon‐Mantel, A., & Milgröm, E. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-699-7_17 · Cited by 5
Progesterone arrested cell cycle progression through progesterone receptor isoform A in pancreatic neuroendocrine neoplasm
Yazdani, S., Kasajima, A., Onodera, Y., McNamara, K. M., Ise, K., Nakamura, Y., Tachibana, T., Motoi, F., Unno, M., & Sasano, H. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.01.003 · Cited by 6
The molecular basis of progesterone receptor action in breast carcinogenesis
Elizalde, P. V., & Proietti, C. J. (2012) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2011-0129 · Cited by 5
An alternative approach for treatment of breast cancer
Swartzendruber, D. E., Retsky, M. W., Wardwell, R. H., & Bame, P. D. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00666009 · Cited by 5
Progesterone Receptors in Normal and Neoplastic Breast
Balleine, R. L., Mote, P. A., Hunt, S. M. N., et al. (2000) · Endocrine Oncology · doi:10.1007/978-1-59259-223-4_3 · Cited by 4
Effects of sex steroids on proliferation in normal mammary tissue
Söderqvist, G. (1998) · Annals of Medicine · doi:10.3109/07853899809002598 · Cited by 63
Hormonal Control of Breast Cancer Cell Cycle Progression
Sutherland, R. L., Hamilton, J. A., Watts, C. K. W., et al. (1994) · Springer eBooks · doi:10.1007/978-3-642-78814-7_3 · Cited by 4
Self-citation
Tgfα: A member of the EGF receptor ligand family
Lee, D. C. (1996) · Growth factors and cytokines in health and disease · doi:10.1016/s1874-5687(96)80014-0 · Cited by 3
Nuclear oncogenes in breast cancer
Dubik, D., Watson, P. H., Venditti, M., et al. (1996) · Cancer treatment and research · doi:10.1007/978-1-4613-1259-8_9 · Cited by 3
Estrogen Sulfotransferase in Breast Cancer
Pasqualini, J. R., & Chetrite, G. S. (2005) · CRC Press eBooks · doi:10.1201/9781420024029.ch8 · Cited by 2
Chapter 4 Progestin regulation of cellular proliferation
Musgrove, E. A., & Sutherland, R. L. (1996) · Advances in oncobiology/Advances in oncobiology (Print) · doi:10.1016/s1569-254x(96)80006-9 · Cited by 2
Self-citation
Progestin Regulation of Cell Proliferation in the Breast and Endometrium
Sutherland, R. L., Lee, C. S. L., Cornish, A. L., et al. (1995) · Springer eBooks · doi:10.1007/978-3-662-09153-1_5 · Cited by 2
Self-citation
Interactions Between Estradiol and Progesterone in Normal Breast
Plu‐Bureau, G., Touraine, P. A., & MAUVAIS-JARVIS, P. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-699-7_2 · Cited by 2
Adventures in myc-ology
Rothberg, P. G., & Heruth, D. P. (1995) · Advances in genome biology · doi:10.1016/s1067-5701(05)80006-3 · Cited by 2
Sein et hormones
Plu‐Bureau, G., Touraine, P. A., & Kuttenn, F. (2006) · EMC - Gynécologie · doi:10.1016/s0246-1064(02)00071-3 · Cited by 1
PR
Laudet, V., & Gronemeyer, H. (2002) · Elsevier eBooks · doi:10.1016/b978-012437735-6/50034-5 · Cited by 1
Expression and Regulation of Cyclin Genes in Breast Cancer Cells
Musgrove, E. A., Buckley, M. F., DeFazio, A., et al. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2421-2_38 · Cited by 1
Self-citation
Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputsPreprint
Dolan, E. L., Safi, R., Chang, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.13.562206 · Cited by 1
Progesterone Receptor Isoforms : functional Selectivity and Pharmacological Targeting
Khan, J. A. (2011) · theses.fr (ABES) · doi:10.70675/d565fcfezaed8z42f4za43az5b89ba52f3ae · Cited by 1
Archaic reflexes in normal elderly people.
Orefice, G., Modafferi, N., Selvaggio, M., et al. (1991) · PubMed · Cited by 1
Hormonsubstitution heute — Das Gestagenperlenspiel
̈Römer, T., Rudolf, K., Schindler, A. E., et al. (2000) · Springer eBooks · doi:10.1007/978-3-642-59688-9_35
Hormone replacement therapy after breast cancer and a review of the therapeutic properties of phyto-estrogens
Eden, J. (1997) · Gynecological Endocrinology · doi:10.3109/09513599709152579
Is there a place for progestin agents in breast cancer prevention?
Gompel, A., Lévy, D., Chaouat, M., et al. (2002) · International Congress Series · doi:10.1016/s0531-5131(01)00467-8
The management of urogenital atrophy following genital tract cancer
Wren, B. G. (1995) · International Urogynecology Journal · doi:10.1007/bf01962572
Defining the role of progesterone receptor and progestin in luminal breast cancer cells
Bajalović, N. (2018) · doi:10.32657/10220/45830
Progesterone and Breast Cancer
(2006) · Science · doi:10.1126/science.314.5804.1349k
Inhibition of Cell Growth and Induction of Apoptosis
Formby, B., & Wiley, T. S. (2002) · Breast Cancer · doi:10.1201/b14039-6
Control of Proliferation in the Normal and Neoplastic Breast
Clarke, R. B., Howell, A., & Anderson, E. L. (2002) · Breast Cancer · doi:10.1201/b14039-4
Mammary Gland
Söderqvist, G., & von Schoultz, B. (1999) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60107-1_4
Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cellsPreprint
Woo, Q. Y., Lau, P. K., Kwong, B. L. T., Bajalović, N., Lee, S. H., Leong, K. S., Pow, K. Y., Hanan, S., Meng, W., Lai, S. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.06.641096
Methylation mimic mutations of progesterone receptor AF1 impair gene-specific regulation through stabilized chromatin interactionsPreprint
Lau, P. K., Kwong, B. L. T., Lee, S. H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.23.684277
Potential Benefits of Estrogen and Progestogen on Malignancy
Schneider, H. P. G., & Jackisch, C. (1997) · Medical science symposia series · doi:10.1007/978-94-011-5560-1_33
Pathologic, Clinical, and Epidemiologic Characteristics of Invasive Lobular Breast Carcinoma and a Review of Studies Evaluating its Association with Hormone Replacement Therapy
Li, C. I. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-23761-5_4

Authors: Musgrove, E. A., Lee, C. S., & Sutherland, R. L.
ORCID: Sutherland, R L
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1991-10
Volume: 11
Issue: 10
Pages: 5032-5043
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.11.10.5032
OpenAlex: W4241665805
Cited by: 175
References: 0
Citations by year: 2025: 2 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 8
FWCI: 2.09
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
Funders: National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: progestins, breast cancer, cell cycle progression, progesterone receptor, T47D cells, G1 phase, cell cycle arrest, growth inhibition, transforming growth factor-alpha, epidermal growth factor receptor, c-fos, c-Myc, proto-oncogenes, autocrine growth factor, RU486, gene expression regulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks