Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters
Open accessAbstract
The Pax-8 gene, a member of the murine family of paired box-containing genes (Pax genes), is expressed in adult thyroid and in cultured thyroid cell lines. The Pax-8 protein binds, through its paired domain, to the promoters of thyroglobulin and thyroperoxidase, genes that are exclusively expressed in the thyroid. In both promoters, the binding site of Pax-8 overlaps with that of TTF-1, a homeodomain-containing protein involved in the activation of thyroid-specific transcription. Pax-8 activates transcription from cotransfected thyroperoxidase and thyroglobulin promoters, indicating that it may be involved in the establishment, control, or maintenance of the thyroid-differentiated phenotype. Thus, the promoters of thyroglobulin and thyroperoxidase represent the first identified natural targets for transcriptional activation by a paired domain-containing protein.
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TTF1 and PAX8 activate TPO transcription by binding to overlapping DNA sites in the promoter, and TTF2 may interfere with their binding to inhibit TPO transcriptional activation.
“TTF1 and PAX8 can activate the transcription of TPO by binding to specific DNA binding sites that overlap each other in the promoter region ( Figure 3C ) (169).”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [169]
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Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61 · see citing works
- Authors
- Zannini, M., Francis-Lang, H., Plachov, D., & Lauro, R. D.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Institute for Molecular Biology, Salzburg, Austria
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1992-09-01
- Volume
- 12
- Issue
- 9
- Pages
- 4230-4241
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC360331
- OpenAlex
- W2100992077
- Cited by
- 300
- References
- 0
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PAX8, paired box genes, paired domain, transcriptional activation, thyroglobulin promoter, TTF-1, homeodomain, thyroid differentiation, thyroid cell lines
- MeSH terms
- Animals, Base Sequence, Binding Sites, DNA, HeLa Cells, Humans, Molecular Sequence Data, Peroxidases, Promoter Regions, Genetic, Thyroglobulin, Thyroid Gland, Transcription Factors, Transcription, Genetic, Blotting, Northern, Rats
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