The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.
Open accessAbstract
In Philadelphia chromosome-positive human leukemias, the c-abl proto-oncogene on chromosome 9 becomes fused to the bcr gene on chromosome 22, and chimeric Bcr-Abl proteins are produced. The fused Bcr sequences activate the tyrosine kinase, actin-binding, and transforming functions of Abl. Activation of the Abl transforming function has been shown to require two distinct domains of Bcr: domain 1 (Bcr amino acids 1 to 63) and domain 2 (Bcr amino acids 176 to 242). The amino acid sequence of domain 1 indicates that it may be a coiled-coil oligomerization domain. We show here that domain 1 of Bcr forms a homotetramer. Tetramerization of Bcr-Abl through Bcr domain 1 correlates with activation of the tyrosine kinase and F-actin-binding functions of Abl. Disruption of the coiled coil by insertional mutagenesis inactivates the oligomerization function as well as the ability of Bcr-Abl to transform Rat-1 fibroblasts or to abrogate interleukin-3 dependence in lymphoid cells. These results strongly suggest that Bcr-Abl oligomers are the active entities in transformation.
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Cites
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Cited by
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Metadata
- Authors
- McWhirter, J. R., Galasso, D. L., & Wang, J. Y.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1993-12
- Volume
- 13
- Issue
- 12
- Pages
- 7587-7595
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2157693529
- Cited by
- 420
- References
- 42
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. https://app.cochat.ai/papers/10.1128/mcb.13.12.7587
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- McWhirter, J. R., Galasso, D. L., & Wang, J. Y. (1993). A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.13.12.7587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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