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Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24
Open accessAbstract
Pheromone signalling in Saccharomyces cerevisiae is mediated by the STE4-STE18 G-protein beta gamma subunits. A possible target for the subunits is Ste20p, whose structural homolog, the serine/threonine kinase PAK, is activated by GTP-binding p21s Cdc42 and Rac1. The putative Cdc42p-binding domain of Ste20p, expressed as a fusion protein, binds human and yeast GTP-binding Cdc42p. Cdc42p is required for alpha-factor-induced activation of FUS1.cdc24ts strains defective for Cdc42p GDP/GTP exchange show no pheromone induction at restrictive temperatures but are partially rescued by overexpression of Cdc42p, which is potentiated by Cdc42p12V mutants. Epistatic analysis indicates that CDC24 and CDC42 lie between STE4 and STE20 in the pathway. The two-hybrid system revealed that Ste4p interacts with Cdc24p. We propose that Cdc42p plays a pivotal role both in polarization of the cytoskeleton and in pheromone signalling.
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Cited by
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Treisman, R. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80067-6 · Cited by 1,296
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Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes
Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T., & Lim, L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1129 · Cited by 561
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Metadata
- Authors
- Zhao, Z.-S., Leung, T., Manser, E., & Lim, L.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-10-01
- Volume
- 15
- Issue
- 10
- Pages
- 5246-5257
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1989292730
- Cited by
- 187
- References
- 0
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, Z.-S., Leung, T., Manser, E., & Lim, L. (1995). Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.15.10.5246
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