The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint
Open accessAbstract
A cdc13 temperature-sensitive mutant of Saccharomyces cerevisiae arrests in the G2 phase of the cell cycle at the restrictive temperature as a result of DNA damage that activates the RAD9 checkpoint. The DNA lesions present after a failure of Cdc13p function appear to be located almost exclusively in telomere-proximal regions, on the basis of the profile of induced mitotic recombination. cdc13 rad9 cells dividing at the restrictive temperature contain single-stranded DNA corresponding to telomeric and telomere-proximal DNA sequences and eventually lose telomere-associated sequences. These results suggest that the CDC13 product functions in telomere metabolism, either in the replication of telomeric DNA or in protecting telomeres from the double-strand break repair system. Moreover, since cdc13 rad9 cells divide at a wild-type rate for several divisions at the restrictive temperature while cdc13 RAD9 cells arrest in G2, these results also suggest that single-stranded DNA may be a specific signal for the RAD9 checkpoint.
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Citations
Cites
DNA sequences of telomeres maintained in yeast
Shampay, J., Szostak, J. W., & Blackburn, E. H. (1984) · Nature · doi:10.1038/310154a0 · Cited by 551
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Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., & Cech, T. R. (1997) · Science · doi:10.1126/science.276.5312.561 · Cited by 1,269
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Metadata
- Authors
- Garvik, B., Carson, M., & Hartwell, L.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-11-01
- Volume
- 15
- Issue
- 11
- Pages
- 6128-6138
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2122658576
- Cited by
- 631
- References
- 1
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint. https://app.cochat.ai/papers/10.1128/mcb.15.11.6128
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- Garvik, B., Carson, M., & Hartwell, L. (1995). Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.15.11.6128
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
