The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Retinoic Acid Receptor β Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells
Open accessAbstract
Retinoids are known to inhibit the growth of hormone-dependent but not that of hormone-independent breast cancer cells. We investigated the involvement of retinoic acid (RA) receptors (RARs) in the differential growth-inhibitory effects of retinoids and the underlying mechanism. Our data demonstrate that induction of RAR beta by RA correlates with the growth-inhibitory effect of retinoids. The hormone-independent cells acquired RA sensitivity when the RAR beta expression vector was introduced and expressed in the cells. In addition, RA sensitivity of hormone-dependent cells was inhibited by a RAR beta-selective antagonist and the expression of RAR beta antisense RNA. Introduction of RAR alpha also restored RA sensitivity in hormone-independent cells, but this restoration was accomplished by the induction of endogenous RAR beta expression. Furthermore, we show that induction of apoptosis contributes to the growth-inhibitory effect of RAR beta. Thus, RAR beta can mediate retinoid action in breast cancer cells by promoting apoptosis. Loss of RAR beta, therefore, may contribute to the tumorigenicity of human mammary epithelial cells.
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Cites
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Background9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
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“All-trans RA and 9-cis RA (28, 45), the two known active derivatives of vitamin A, essentially function as hormones by interacting with specific retinoid receptors.”
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Cited by
van Meerbeeck, J. P., Fennell, D. A., & De Ruysscher, D. K. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60165-7 · Cited by 1,237
Jackman, D. M., & Johnson, B. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67569-1 · Cited by 503
Retinoids regulate stem cell differentiation
Gudas, L. J., & Wagner, J. A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22417 · Cited by 395
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells
Cañón, E., Cosgaya, J. M., Scsucova, S., & Aranda, A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0439 · Cited by 184
Metadata
- Authors
- Liu, Y., Lee, M.-O., Wang, H.-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J. C., & Zhang, X.-K.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 1138-1149
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2125976258
- Cited by
- 329
- References
- 73
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Retinoic Acid Receptor β Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells. https://app.cochat.ai/papers/10.1128/mcb.16.3.1138
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- Liu, Y., Lee, M.-O., Wang, H.-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J. C., & Zhang, X.-K. (1996). Retinoic Acid Receptor β Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.16.3.1138
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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