Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

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7. Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3
   Miao Wang, Xiao‐Wei Li, Sen-Chao Yuan, Jie Pan, Zeng-Lin Guo, Li-Ming Sun, Shao-Zhen Jiang, Ming Zhao, Wen Xue, Hong Cai et al. · 2024 · Journal of Molecular Cell Biology
8. Type I interferon system and IRF family of transcription factors in host defense regulation
   Tadatsugu Taniguchi, Akinori Takaoka · 2005 · Proceedings of the Japan Academy Series B
9. CuRTAiling Interferon Regulatory Factor Signaling with the E3 Ligase RAUL
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10. Costunolide inhibits interferon regulatory factor 3 activation induced by lipopolysaccharide and polyinosinic-polycytidylic acid
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    Peng Yuan, Zhou Yang, Yang Yang · 2018 · Gastroenterology Hepatology and Endoscopy
13. Mechanisms of Transcriptional Regulation
    Sylvia Marecki, Matthew J. Fenton · 2000
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    Phạm Hoàng Sơn Hưng, Yusuke FUJII, Kensuke Arakawa · 2021 · Bioscience of Microbiota Food and Health
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    Xibao Shi, Yuqi Xing, Hao Chen et al. · 2025 · Microbial Pathogenesis
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    S. Arutkumaran, Rajib Deb, S. Shanmathi, G. Sengar, Soumendu Chakravarti, P. J. Das, S. Pegu, A. Reis, V. K. Gupta · 2025 · Microbial Pathogenesis
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    Mohamed Labib Salem, Said M. Hammad, Mohamed Ramadan El-Shanshory, Mohamed A. Attia, Abdel‐Aziz A. Zidan · 2014 · InTech eBooks
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    James D. Marion · 2014 · Springer eBooks
27. Anti-viral approaches against influenza viruses
    Stephan Pleschka, Stephan Ludwig, Thorsten Wolff, Oliver Planz · 2006 · Springer eBooks
28. Suppression of TLRs signaling pathways by 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine
    Sang‐Il Ahn, Ji-Soo Kim, Hyeon‐Myeong Shin et al. · 2016 · International Immunopharmacology
29. Eicosapentaenoic acid suppresses TRIF-dependent signaling pathway of TLRs by targeting TBK1
    Hyeon‐Myeong Shin, Hyun‐Jin Shim, Ah-Yeon Kim · 2017 · Journal of Food Biochemistry
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    Arran Hodgkinson, Gilles Uzé, Ovidiu Radulescu · 2018 · Bulletin of Mathematical Biology
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    Xianqing Sun, Peng Qiu, Zhennan He · 2024 · Apmis
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    Ingvild Bjellmo Johnsen, Bjarte Bergstrøm, Kim André Ha Stiberg, Liv Thommesen, Marit Walbye Anthonsen · 2013 · Cellular Signalling
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    de Araujo Lobo, Jaime Matias · 2012
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    Hong-Ping Liang, Hak Hotta, Jian-Min Ji · 2018 · European Journal of Inflammation
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    Se‐Jeong Park · 2009
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    Jielan Jiang, Jia Wen Xu, Yumeng Liu · 2022 · Aquaculture Research
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    Joan E. Durbin · 2014 · ASM Press eBooks
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    Judith G. Alamares · 2008 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
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    Dang Wang, Liurong Fang, Ping Li · 2010 · Developmental & Comparative Immunology
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    Tina Svingerud · 2013 · NORA - Norwegian Open Research Archives
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    John Hiscott, Rongtuan Lin · 2006 · Expert Review of Clinical Immunology
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    Nathan R. Zemke, William D. Barshop, Jihui Sha, Emily Hsu, James Akira Wohlschlegel, Arnold J. Berk · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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    Charles R. Dixon, Poonam R. Malik, Jose I. de las Heras et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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    Yumin Han, Fangfei Peng, Yunqi Chang, Tingting Liu, Jiayan Shen, Zizhuo Chen, Qian Dong, Ping Zhou, Feng Jiang, Honggang Xiang et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
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    Jaime M. de Araújo Lobo · 2012
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    Paula M. Pitha · 2004 · Folia Biologica
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    Emmalene J. Bartlett · 2002 · Murdoch University Research Portal
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    Eileen Clifford · 2010 · Maynooth University ePrints and eTheses Archive (Maynooth University)
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    Tristan A. Scott · 2014 · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
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    Qiong A Wang · 2010 · Deep Blue (University of Michigan)
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    Jana L. Jacobs · 2014 · D-Scholarship@Pitt (University of Pittsburgh)
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    Claudia Wietek, Luke A.J. O'Neill · 2007 · Springer eBooks
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    Taija E. Pietilä · 2010 · Työväentutkimus Vuosikirja
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    Yibin Yang · 2010 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
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    Min-Hi Lee · 2009
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    Stanley M. Lemon · 2014 · ASM Press eBooks
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    Stephen Hickling, Rodney Phillips · 2011 · Springer eBooks
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    Brenda L. Fredericksen, Michael Gale · 2014 · ASM Press eBooks
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    Kasey Michelle Eidson · 2006 · D-Scholarship@Pitt (University of Pittsburgh)
65. The rabies virus phosphoprotein P: a key regulator of innate immune responses
    Krzysztof D. Brzózka · 2006
66. Viral interferon regulatory factors inhibit the immune response following rhesus rhadinovirus infection
    Bridget A. Robinson · 2014
67. Identification of an Antiviral Signaling Variant Demonstrates Immune Regulation Through Alternative Translation
    Sky W. Brubaker · 2014 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
68. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins
    Antonella Casola, Xiaoyong Bao, Allan R. Brasier, Roberto P. Garofalo · 2014 · ASM Press eBooks
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    Devangi R. Mehta · 2011 · MacSphere (McMaster University)
70. Triptolide inhibits inducible nitric oxide synthase expression induced by toll-like receptor agonists
    Gyo‐Jeong Gu, Sang-Hoon Eom, Hyung‐Sun Youn · 2013 · Toxicology and Environmental Health Sciences
71. INTERFERON-ALPHA SIGNALING PATHWAY IN THE SENSORY AUDITORY NEUROEPITHELIAL CELLS
    Mona Anwar M. H. El-Kady · 2010 · D-Scholarship@Pitt (University of Pittsburgh)
72. The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection
    Vineet D. Menachery · 2010 · Open Scholarship Institutional Repository (Washington University in St. Louis)
73. Rotavirus NSP1 is an interferon system antagonist
    Joel W. Graff · 2008 · Montana State University ScholarWorks (Montana State University)
74. Cigarett e Smoke Suppresses Type I Interferon- Mediated Antiviral Immunity in Lung Fibroblast
    Epithelial Cells · 2008
75. Negative Regulators of NF-κB Activation and Type I Interferon Pathways
    Caroline Murphy, Luke A.J. O'Neill · 2011 · Springer eBooks
76. Transcriptional regulation of type I interferon responses of myeloid antigen presenting cells
    Wei Xiang Sin · 2016 · DR-NTU (Nanyang Technological University)
77. L’étude de l’impact des protéines non structurales NS1 et NS2 du virus respiratoire syncitial sur la réponse immunitaire innée
    Fabrice Yoboua · 2012 · Papyrus : Institutional Repository (Université de Montréal)
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    Ro Shauna Rothwell · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
79. Regulations of Interferon Regulatory Factor 7 by Viral and Cellular Proteins
    Qiming Liang · 2011
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    Tina Mahieu · 2006 · Ghent University Academic Bibliography (Ghent University)
81. Posttranslationale Kontrolle des zellulären Transkriptionsfaktors PBF/ZNF395
    Mathematisch-naturwissenschaftlichen Fakultät I · 2012
82. INFLAMMATORY BOWEL DISEASES: Genetic Markers and their Use in Predicting Disease Course, Response to Treatment, and Need for Surgery
    Simon Fischer, Peter Laszlo Lakatos · 2008
83. Augmenting the effector phase of adoptive T cell immunotherapy of cancer
    Kevin M. Friedman · 2009
84. Negative regulation of host innate antiviral signaling
    Qinjie Zhou · 2015
85. Helicases at Frontline of RNA Virus Recognition
    Marco Colonna, Leonid Gitlin · 2008 · CRC Press eBooks
86. Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex
    Nicholas Peters · 2011 · Spiral (Imperial College London)
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    Daniel Mark Andrews · 2004 · UWA Profiles and Research Repository (University of Western Australia)
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    Brendan J. Hilbert · 2013 · eScholarship@UMassChan
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    Christina L. Kirkham · 2017 · TSpace (University of Toronto)
90. Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
    Sandra N. Lester · 2016
91. Genetic networks of antibacterial responses of eukaryotic cells. Bioinformatics analysis and modeling
    Ekaterina Shelest · 2006 · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG))
92. Structural and Non-Structural Proteins of Porcine Epidemic Diarrhea Virus against Congenital Immunity of Host Cells
    芃 袁 · 2018 · Advances in Microbiology
93. Characterization of pellino1 and pellino2 in toll-like receptor signaling
    Liang Xiang Dai · 2012 · DR-NTU (Nanyang Technological University)
94. BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
    Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
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    Marni S. Crow · 2018
96. Viral mimicry of p65/RelA transactivation domain to inhibit NF-κB activation
    Jonas Dutra Albarnaz, Hongwei Ren, Alice A. Torres · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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    Yanna Xiao · 2019 · ERA: Education and Research Archive (University of Alberta)
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    Alexandr Nasedkin · 2014 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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    Kevin Klann · 2021 · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
100. Faculty Opinions recommendation of LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
     David M. Underhill · 2003 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature