The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin
Open accessAbstract
Wnt signaling is thought to be mediated via interactions between beta-catenin and members of the LEF-1/TCF family of transcription factors. Here we study the mechanism of transcriptional regulation by LEF-1 in response to a Wnt-1 signal under conditions of endogenous beta-catenin in NIH 3T3 cells, and we examine whether association with beta-catenin is obligatory for the function of LEF-1. We find that Wnt-1 signaling confers transcriptional activation potential upon LEF-1 by association with beta-catenin in the nucleus. By mutagenesis, we identified specific residues in LEF-1 important for interaction with beta-catenin, and we delineated two transcriptional activation domains in beta-catenin whose function is augmented in specific association with LEF-1. Finally, we show that a Wnt-1 signal and beta-catenin association are not required for the architectural function of LEF-1 in the regulation of the T-cell receptor alpha enhancer, which involves association of LEF-1 with a different cofactor, ALY. Thus, LEF-1 can assume diverse regulatory functions by association with different proteins.
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Cites
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Self-citationFagotto, F., Glück, U., & Gumbiner, B. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70082-x · Cited by 434
Mayall, T. P., Sheridan, P. L., Montminy, M. R., & Jones, K. A. (1997) · Genes & Development · doi:10.1101/gad.11.7.887 · Cited by 118
Cited by
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839
TCF/LEFs and Wnt Signaling in the Nucleus
Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 760
Balancing cell adhesion and Wnt signaling, the key role of β-catenin
Brembeck, F. H., Rosário, M., & Birchmeier, W. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.007 · Cited by 668
Metadata
- Authors
- Hsu, S.-C., Galceran, J., & Grosschedl, R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1998-08-01
- Volume
- 18
- Issue
- 8
- Pages
- 4807-4818
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2141175150
- Cited by
- 363
- References
- 3
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Hsu, S.-C., Galceran, J., & Grosschedl, R. (1998). Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with β-Catenin. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.18.8.4807
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