HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor
Open accessAbstract
Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similarity to the deacetylase domain of yeast HDA1. HDAC4 is expressed in various adult human tissues, and its gene is located at chromosome band 2q37. HDAC4 possesses histone deacetylase activity intrinsic to its C-terminal domain. When tethered to a promoter, HDAC4 represses transcription through two independent repression domains, with repression domain 1 consisting of the N-terminal 208 residues and repression domain 2 containing the deacetylase domain. Through a small region located at its N-terminal domain, HDAC4 interacts with the MADS-box transcription factor MEF2C. Furthermore, HDAC4 and MEF2C individually upregulate but together downmodulate c-jun promoter activity. These results suggest that HDAC4 interacts with transcription factors such as MEF2C to negatively regulate gene expression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Attempts to obtain active recombinant class IIa HDACs in heterologous systems were unsuccessful.
“Attempts to obtain active recombinant class IIa HDACs in heterologous systems were also unsuccessful (21).”
From Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases (2007) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 65 · Cited by 294
Research works printed but not linked: 1
- [53]van Holde K E. Chromatin. Berlin, Germany: Springer-Verlag; 1989. [Google Scholar]
- Authors
- Wang, A. H., Bertos, N. R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H. H., Th’ng, J., Han, J., & Yang, X.-J.
- Affiliations
- McGill University (CA)
- Molecular Oncology Group, Department of Medicine
- Lady Davis Institute for Medical Research (CA)
- York University (CA)
- Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec
- Scripps Research Institute (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1999-11-01
- Volume
- 19
- Issue
- 11
- Pages
- 7816-7827
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC84849
- OpenAlex
- W2129504578
- Cited by
- 294
- References
- 65
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 7 · 2022: 14 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- HDAC4, histone deacetylase, Hda1, histone acetylation, corepressors, transcriptional repression, repression domain, MEF2C, MADS-box transcription factors, c-jun promoter, chromatin structure, gene expression regulation
- MeSH terms
- Amino Acid Sequence, Chromosome Mapping, Chromosomes, Human, Pair 2, Cloning, Molecular, DNA-Binding Proteins, Gene Expression Regulation, Multigene Family, Histone Deacetylases, Humans, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Repressor Proteins, Tissue Distribution, Transcription Factors, Transcription, Genetic, Proto-Oncogene Proteins c-jun, Sequence Homology, Amino Acid, In Situ Hybridization, Fluorescence, Myogenic Regulatory Factors, MADS Domain Proteins, MEF2 Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
